Giuseppe Roberto Burgio

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Four boys are described with partial gigantism of the hands and/or feet, pigmented nevi, hemihypertrophy, subcutaneous hamartomatous tumors and macrocephaly, and/or other skull anomalies. Three of these patients showed an accelerated growth in their first years of life. Two suffered from cystiform pulmonary abnormalities. The children showed normal mental(More)
Subjects with Down syndrome (DS) have a high mortality due to infections and a high risk of developing malignancies. These observations, together with the demonstration of a frequent occurrence of HBsAg carrier state and of autoantibodies, have prompted investigations of the immune function in DS. Thymic morphological and functional abnormalities have been(More)
Fifty children with IgA deficiency were followed for 1 to 4 years from 1975 to 1978. Thirty-five had complete deficiency of serum IgA (<2.5 IU/ml) and 15 partial deficiency (serum IgA below the 10th centile for age). Patients with another associated immunodeficiency, such as ataxia-telangiectasia, were not included. Most children with complete deficiency of(More)
We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P less than 0.00001(More)
Antiphospholipid antibodies, i.e. circulating auto-antibodies to negatively charged phospholipids, are mainly observed in patients with systemic lupus erythematosus, but may also occur in individuals who lack evidence of a well-defined systemic disease. Several studies have suggested that they may play a direct role in the pathogenesis of recurrent vascular(More)
s of the 3rd International Symposium on<lb>Therapy of Acute Leukemias, Rome, 1982; 265.<lb>18. Koocher GT, O’Malley JE, Gogan JL, Foster DJ. Psycho-<lb>logical adjustment among pediatric cancer survivors. ]<lb>Child Psycho1 Psychiatry 1980; 21: 163-173.<lb>19. Slavin LA, O’Malley JE, Koocher GP, Foster DJ. Commu-<lb>nication of the cancer diagnosis to(More)
Wise G (1980) An improved method for the assay of platelet pyruvate dehydrogenase. Clin Chim Acta 108:219-227 13. Scholte HR, Busch HFN, Barth PG, Beekman RP, Berden JA, Duran M, Luyt-Houwen IEM, Przyrembel H, Roth B, de Vries S (1983) Carnitine deficiency and mitochondrial respiratory chain blockade. In: Scarlato G, Cerri C (eds) Mitochondrial pathology in(More)
Four boys are described with partial gigantism of the hands and/or feet, pigmented nevi, hemihypertrophy, subcutaneous hamartomatous tumors and macrocephaly, and/or other skull anomalies. Three of these patients showed an accelerated growth in their first years of life. Two suffered from cystiform pulmonary abnormalities. The children showed normal mental(More)
La reattività alla fitoemoagglutinina e la capacità di formare «rosette» con eritrociti di montone dei linfociti di sangue periferico è risultata significativamente depressa in soggetti adulti affetti da sindrome di Down. Si può ritenere che la funzione timo-dipendente vada incontro in questi pazienti ad un deterioramento assai più rapido che nella(More)