Giuseppe Mensitieri

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In this work, the silylation of sodium montmorillonite (Na-MMT) was performed in glycerol using 3-aminopropyltriethoxysilane, N-(2-aminoethyl)-3-aminopropyltrimethoxysilane and 3-[2-(2-aminoethylamino)ethylamino]-propyl-trimethoxysilane. The effects on the d-spacing of sodium montmorillonite (Na-MMT) upon reaction with three aminosilanes of different chain(More)
An interpretation of the drug release from monolithic water-swellable and soluble polymer tablets is presented. A convenient parameter, alpha, which compares the drug-diffusive conductance in the gel layer with the swelling and dissolving characteristics of the unpenetrated polymer was used to describe the release behaviour of beta-hydroxyethyl-theophylline(More)
A simple approach is presented to modulate drug delivery from swellable systems by using complexants. The effect of complexants has been interpreted by means of simple mass balances on diffusing species and the involved relevant parameters have been individuated. The application of this strategy to the release of nicardipine (NIC) from swellable systems by(More)
The aim of this work was to develop a tablet for the buccal delivery of the poorly soluble drug carvedilol (CAR), based on poly(ethyleneoxide) (PEO) as bioadhesive sustained-release platform and hydroxypropyl-beta-cyclodextrin (HPbetaCD) as modulator of drug release. As first, PEO tablets loaded with CAR/HPbetaCD binary systems with different dissolution(More)
Sorption thermodynamics of water in two glassy polymers, polyetherimide (PEI) and polyetheretherketone (PEEK), is investigated by coupling gravimetry and on line FTIR spectroscopy in order to gather information on the total amount of sorbed water as well as on the different species of water molecules absorbed within the polymers, addressing the issue of(More)
Sorption of water in poly(ε-caprolactone) (PCL), with specific focus on the hydrogen-bonding interactions, has been analyzed by combining ab initio calculations, macroscopic thermodynamics modeling, and relevant features emerging from spectroscopic and gravimetric measurements. Fourier transform infrared (FTIR) data, analyzed by difference spectroscopy,(More)
Chemical sensors are generally based on the integration of suitable sensitive layers and transducing mechanisms. Although inorganic porous materials can be effective, there is significant interest in the use of polymeric materials because of their easy fabrication process, lower costs and mechanical flexibility. However, porous polymeric absorbents are(More)
In-situ Fourier transform infrared (FTIR) measurements have been carried out at different relative pressures of water vapor to study the H(2)O diffusion in three polyimides differing in their molecular structure and fluorine substitution. Spectral data have been analyzed by difference spectroscopy, least-squares curve fitting, and two-dimensional (2D)(More)
Self-assembling of reduced graphene oxide platelets, as a tailored interconnected network within a natural rubber matrix, is proposed as a mean for obtaining nanocomposites with improved gas barrier, as compared to neat natural rubber. Interestingly, this nanocomposite structure results to be much more effective than homogeneous dispersion of graphene(More)