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OBJECTIVE In randomized studies of heterogeneous patients with hypoxemic acute respiratory failure, noninvasive positive pressure ventilation (NPPV) was associated with a significant reduction in endotracheal intubation. The role of NPPV in patients with acute respiratory distress syndrome (ARDS) is still unclear. The objective was to investigate the(More)
PURPOSE To systematically review the published evidence on the ability of passive leg raising-induced changes in cardiac output (PLR-cCO) and in arterial pulse pressure (PLR-cPP) to predict fluid responsiveness. METHODS MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews were screened. Clinical trials on human adults published as full-text(More)
In this paper an extensive experimental evaluation of an evolutionary approach t o c o n-cept learning is presented. The experimentation , performed with the system G-NET, investigates the eeectiveness of the approach along the following dimensions: Robustness with respect to parameter setting, eeective-ness of the MDL criterion coupled with a stochastic(More)
OBJECTIVE To compare the effectiveness of traditional and online teaching methods for educating anesthesiology residents in the principles and practice of difficult airway management. DESIGN Prospective, randomized, controlled trial. SETTING University hospital. PARTICIPANTS Two randomly selected groups, each containing 28 physicians enrolled from(More)
Culture-independent molecular techniques such as real-time PCRs offer the potential for early diagnosis of invasive aspergillosis (IA), thereby reducing the disease-associated mortality rate. PCR-based testing is presently excluded from disease-defining consensus criteria due to lack of standardization and clinical validation. A single-center prospective(More)
OBJECTIVE To compare the outcomes and the short- and long-term complications of percutaneous translaryngeal tracheostomy (TLT) and surgical tracheostomy (ST). DESIGN Prospective, randomized clinical trial with 1-yr double-blind follow-up. SETTING A general intensive care unit of a university hospital. PATIENTS A total of 139 consecutive critically ill(More)
Despite more than sixty years of scientific medical research, severe pneumonia, either community-acquired or nosocomial, remains a leading cause of death regardless of the patients' immunity state. The clinical introduction of new and more potent antibiotic molecules and the continuous development of efficient respiratory assistance devices may not be able(More)
During critical illness, patients with no known history of thyroid disorders may experience multiple alterations in their serum thyroid hormone levels. Such alterations have been termed sick euthyroid syndrome or, more recently, non-thyroidal illness syndrome (NTIS). The laboratory parameters of NTIS usually include low serum levels of triiodothyronine(More)
PURPOSE OF REVIEW Severe pneumonia is a common disease that intensive care physicians have to face. The review highlights recent findings about microbiology, diagnosis and treatment, including the management of critically ill patients with severe respiratory failure. RECENT FINDINGS Epidemiological and clinical risk factors strongly influence(More)
BACKGROUND The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with(More)