Giuseppe Irrera

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A novel ontology based type 2 diabetes risk analysis system framework is described, which allows the creation of global knowledge representation (ontology) and personalized modeling for a decision support system. A computerized model focusing on organizing knowledge related to three chronic diseases and genes has been developed in an ontological(More)
BACKGROUND The impact of the use of anti-thymocyte globulin (ATG) in allogeneic stem cell transplantation performed with HLA-identical sibling donors following fludarabine and 4 days intravenous busulfan myeloablative conditioning regimen has been poorly explored. METHODS We retrospectively analyzed 566 patients who underwent a first HLA-identical(More)
Hodgkin lymphoma (HL) is a potentially curable lymphoma, and modern therapy is expected to successfully cure more than 80% of the patients. Second-line salvage high-dose chemotherapy and autologous stem cell transplantation (auto-SCT) have an established role in the management of refractory and relapsed HL, leading to long-lasting responses in approximately(More)
et al. Low JAK2V617F allele burden in primary myelofibrosis, compared to either a higher allele burden or unmutated status, is associated with inferior overall and leukemia-free survival. A, Campanelli R et al. A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and(More)
Acute graft-versus-host disease (aGvHD) is a serious systemic complication of allogeneic hematopoietic stem cell transplantation (HSCT) that occurs when alloreactive donor-derived T cells recognize host-recipient antigens as foreign. The early events leading to GvHD seem to occur very soon, presumably within hours from the graft infusion. Therefore, when(More)
Background Patients with Type 2 diabetes mellitus (T2DM) have an early endothelial dysfunction associated with poor wound healing rate. Diabetic ulcers often fail to heal, and the mechanism is not well explained because studies of ulcer wounds in humans are limited as a result of the difficulty of obtaining tissue samples. Peripheral blood (PB) can be(More)
Background Some evidence supports vascular aging as an independent risk factor for cardiovascular morbidity and mortality. Endothelial progenitor cells (EPCs) are a subset of bone-marrow cells that are thought to play an important role in improving the endothelial function. In particular, it has been shown that EPCs recruited into ischemic tissues promote(More)
Background It is now well-known that a critical part of normal healing for cutaneous wounds is the formation of new blood vessels. As implantation of autologous bone marrow (BM)-derived Endothelial Progenitor Cells (EPC) into ischemic limbs has become a promising treatment for moderate to severe peripheral arterial occlusive disease (PAD), we have begun a(More)
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