Giuseppe Desogus

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Lysyl-tRNA synthetase is a member of the class II aminoacyl-tRNA synthetases and catalyses the specific aminoacylation of tRNA(Lys). The crystal structure of the constitutive lysyl-tRNA synthetase (LysS) from Escherichia coli has been determined to 2.7 A resolution in the unliganded form and in a complex with the lysine substrate. A comparison between the(More)
Aminoacyl-tRNA synthetases play a key role in protein biosynthesis by catalyzing the specific aminoacylation of tRNA. The energy required for the formation of the ester bond between the amino acid carboxylate group and the tRNA acceptor stem is supplied by coupling the reaction to the hydrolysis of ATP. Lysyl-tRNA synthetase from Escherichia coli belongs to(More)
INTRODUCTION The aim of this study was to determine the seroprevalence of anti-HEV antibodies in humans sera and to study HEV prevalence in swine from different Sardinian farms, testing viral HEV-RNA in bile samples. METHODS In the first six months of 2008, 532 subjects of whom 402 blood donors and 130 workers at zoonotic risk, were enrolled. Anti-HEV(More)
We report the identification and characterisation of a DNA primase from the thermophilic methanogenic archaeon Methanococcus jannaschii (Mjpri). The analysis of the complete genome sequence of this organism has identified an open reading frame coding for a protein with sequence similarity to the small subunit of the eukaryotic DNA primase (the p50 subunit(More)
The age of European existing building stock and the very low growth rate make energy retrofit a critical issue at the moment. The spreading of good practices is strongly hampered by their cost effectiveness. National legislation thermal requirements for retrofitting works play a fundamental role. If they are too strict, the initial economic investment could(More)
In Europe and worldwide several legislations are adopting comfort models that include the variability of occupants behaviour based on the external climate conditions. The latest adaptive comfort methods consider outdoor temperature not only as a steady variable but also as the representation of occupants past thermal history. The paper presented deals with(More)
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