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We present optical and near-infrared photometry and spectroscopy of the Type Ia SN 2003cg, which exploded in the nearby galaxy NGC 3169. The observations cover a period between-8.5 and +414 days post-maximum. SN 2003cg is a normal but highly-reddened Type Ia event. Its B magnitude at maximum B max =15.94±0.04 and ∆m 15 (B) obs = 1.12±0.04 (∆m 15 (B)(More)
Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is thought to be mediated primarily by the generation of nuclear DNA adducts, which, if not repaired, cause cell death as a consequence of DNA replication and transcription blockage. However, the ability of(More)
We investigate how a different calibration of the Cepheid Period-Luminosity (PL) relation taking into account the metallicity corrections, affects the absolute magnitude calibration of Supernovae (SNe) Ia and, in turn, the determination of the Hubble constant H 0. We exploit SN Ia light curves from literature and previously unpublished data, to build the M(More)
A number of supernovae, classified as Type II, show remarkably peculiar properties such as an extremely low expansion velocity and an extraordinarily small amount of 56 Ni in the ejecta. We present a joint analysis of the available observations for two of these peculiar Type II supernovae, SN 1997D and SN 1999br, using a comprehensive semi-analytic method(More)
The down-regulation of miR-199 occurs in nearly all primary hepatocellular carcinomas (HCCs) and HCC cell lines in comparison with normal liver. We exploited this miR-199 differential expression to develop a conditionally replication-competent oncolytic adenovirus, Ad-199T, and achieve tumor-specific viral expression and replication. To this aim, we(More)
HIV-1 associated neurocognitive disorders (HAND) are a major complication of HIV-1 infection. The mechanism(s) underlying HAND are not completely understood but, based on in vitro studies, the HIV-1 Tat protein may play an important role. In this study, the effect of prolonged exposure to endogenously produced Tat in the brain was investigated using a(More)
Malignant perivascular epithelioid cell tumor (PEComa) is a rare tumor composed of hybrid tumor cells characterized by immunoreactivity for both melanocytic and smooth muscle markers. This paper describes the uncommon esophageal location of an 8 cm PEComa in a 75-year-old Caucasian man who was presented with ingravescent dysphagia. Although PEComas arising(More)
BACKGROUND The therapeutic HIV-1 Tat protein vaccine is in advanced clinical development. Tuberculosis, the main AIDS co-infection, is highly endemic in areas where AIDS prevention through vaccination is needed. However, safety and immunogenicity of Tat vaccination in the course of Mycobacterium tuberculosis (Mtb) infection is still unknown and it prevents(More)
Gaia is a cornerstone mission in the science programme of the European Space Agency (ESA). The spacecraft construction was approved in 2006, following a study in which the original interferometric concept was changed to a direct-imaging approach. Both the spacecraft and the payload were built by European industry. The involvement of the scientific community(More)
The Gaia-ESO survey (GES) is now in its fifth and last year of observations, and has already produced tens of thousands of high-quality spectra of stars in all Milky Way components. This paper presents the strategy behind the selection of astrophysical calibration targets, ensuring that all GES results on radial velocities, atmospheric parameters, and(More)
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