Giulio L. Cantoni
Highly Influential Citations110
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Biological methylation is a broad subject that spans two principal areas of metabolism. First is a series of reactions leading to the biosynthesis of methionine (methylation of homocysteine) and then… Continue Reading
Enzymatic activation of methionine has been clearly established as a prerequisite for the transfer of the methyl group of this compound to a variety of methyl acceptors (1). The reaction involves an… Continue Reading
The genetic locus ahcY, encoding the enzyme S-adenosyl-L-homocysteine hydrolase (EC 126.96.36.199) from the bacterium Rhodobacter capsulatus, has been mapped by mutational analysis to within a cluster of… Continue Reading
S-Adenosylhomocysteine (AdoHcy) (Fig. 1) was first identified as one of the products of the reactions that utilize S-adenosylmethionine (AdoMet) as a methyl donor by Scarano and Cantoni1 in 1954.… Continue Reading