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OBJECTIVE (1) To assess cognitive function and cerebral magnetic resonance imaging (MRI) involvement in relapsing-remitting multiple sclerosis; (2) to monitor disease evolution, cognitive dysfunction, and cerebral lesion burden over time (mean 8.5 year follow up period); (3) to study the relation between clinical, neuropsychological, and MRI data. On follow(More)
OBJECTIVE Hypercholesterolemia (total cholesterol ≥ 200 mg/dl) is a significant risk factor for ischemic heart, cerebrovascular, and peripheral vascular disease. Increased cholesterol in the glandular secretion has been postulated to be necessary for the development of meibomian gland dysfunction (MGD), a common form of chronic blepharitis. The purpose of(More)
Our aim was to describe socio-economic and behavioural factors related to caries experience in school children in Sassari, Sardinia (Italy). Four hundred and three 12-year-old schoolchildren were randomly selected and their teeth clinically examined after air drying, under standard light using a plain mirror and WHO community periodontal index for treatment(More)
This paper describes the dental health status of Italian 4-year-olds in 2004/2005 and analyzes the association between caries in preschool children and some background characteristics in children and parents. Caries was recorded according to WHO criteria. 5,538 subjects were examined. Information on the children's and their parents' social, behavioral,(More)
BACKGROUND Cytomegalovirus (CMV) infection is the most frequent congenital infection in humans. Its prevalence and the frequency of disabling sequelae must be assessed in different populations to permit the formulation or assessment of preventive measures. OBJECTIVES To check the prevalence of congenital infection and seroprevalence in Italy; to verify(More)
BACKGROUND Traditional approaches to the analysis of dmfs/DMFS count data pose analytical challenges, considering the increasing proportion of zeroes in the distribution. The aim of this paper was to predict the probability of 'caries-free' subjects and the dependence of dmfs index on the influence of childhood sociodemographic factors, through the(More)
A descriptive epidemiological survey was extended to the whole province of Sassari, northern Sardinia between latitudes 40 degrees 30' N and 41 degrees N. Results showed a crude total prevalence rate of 144.4 per 100000 on prevalence day (31 December 1997), and an onset-adjusted prevalence rate of 149.7 per 100000. The total average annual incidence rate(More)
UNLABELLED Down-regulation of the liver-specific MAT1A gene, encoding S-adenosylmethionine (SAM) synthesizing isozymes MATI/III, and up-regulation of widely expressed MAT2A, encoding MATII isozyme, known as MAT1A:MAT2A switch, occurs in hepatocellular carcinoma (HCC). Here we found Mat1A:Mat2A switch and low SAM levels, associated with CpG hypermethylation(More)
OBJECTIVES To update prevalence and incidence rates of MS among Sardinians. MATERIALS AND METHODS The present work is a "spider" kind of population based survey, conducted over the interval 1968-97, on patients with MS (Poser criteria) living in the province of Sassari, Northern Sardinia (454,904 population). RESULTS A crude total prevalence rate of(More)
Studies suggested the intake of Cd from diet can be approximately equivalent to that from smoking. Moreover, a mutual metabolic influence between Cd and nutrients has been reported. The purpose of this study was to evaluate the relationship between blood cadmium concentration (BCdC) and food consumption, nutrients intake (Ca, Fe, Zn, vitamin C, and vitamin(More)