Giuliana Scarpati

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The complex picture of inflammation and coagulation alterations comes to life in acute stroke phases. Increasing evidence points to a strong interaction and extensive crosstalk between the inflammation and coagulation systems: the interest towards this relationship has increased since recent experimental research showed that the early administration of(More)
Arginine vasopressin (AVP) and its synthetic, long-acting analog terlipressin (TP) are potent alternative vasoconstrictors in the treatment of septic patients with catecholamine-refractive vasodilatatory shock. Recent clinical data suggest that early administration of AVP analogues may be advantageous compared to a last resort therapy. However, it is still(More)
BACKGROUND Metabolic management of brain-death organ donors includes correction of the hormonal perturbations that occur after cerebral death and impair circulatory function. Vasopressin is a hormone secreted by the posterior pituitary gland, which contributes to maintain systemic blood pressure by regulating urine secretion and small arteriole tonus.(More)
OBJECTIVES Restoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery. MATERIAL AND METHODS A subjective, not systematic, review of literature was performed. Papers(More)
Translational Research means different things to different people, but it seems crucial to almost everyone. This discipline, although defined differently in academia, regulatory institutions, and industry, shares the fundamental vision of Translational Medicine, which efficiently and effectively translates basic scientific findings relevant to human disease(More)
32 Università degli Studi di Salerno "Stubbing pain in the hands, finger joints blocked, severe pain in the back and knees, insomnia, depression. The life of Dr. Jacqueline Lagacé, like that of millions of people suffering from arthritis and osteoarthritis, is an ordeal, until the day he encounters in the hypotoxic diet Dr. Seignalet and decided to try it"(More)
PURPOSE To develop a clinically relevant porcine model for the study of hepatic metabolism of drugs by means of hepatic vein catheterization. MATERIALS AND METHODS review of literature and elaboration of a hypothesis, design of an experimental method. RESULTS recent clinical studies were conducted by withdrawing cirrhotic patients' blood from right(More)
Objectives: Restoration of circulation is crucial in the surgical patient management. Colloids and crystalloids are widely used for blood volume therapy. We reviewed recent trials to evaluate efficacy and safety of hydroxyethyl starch (HES) 130/0.4 during surgery. Material and methods: A subjective, not systematic, review of literature was performed. Papers(More)
The complex picture of inflammation and coagulation alterations comes to life in acute stroke phases. Increasing evidence points to a strong interaction and extensive crosstalk between the inflammation and coagulation systems: the interest towards this relationship has increased since recent experimental research showed that the early administration of(More)
From single to multicellular organisms, protective mechanisms have evolved against endogenous and exogenous noxious stimuli. Over the past decades numerous signaling pathways by which the brain senses and reacts to such insults as neurotoxins, substrate deprivation and inflammation have been discovered. Research on preconditioning is aimed at understanding(More)
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