Giuliana Indelicato

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Key steps in a viral life-cycle, such as self-assembly of a protective protein container or in some cases also subsequent maturation events, are governed by the interplay of physico-chemical mechanisms involving various spatial and temporal scales. These salient aspects of a viral life cycle are hence well described and rationalised from a mesoscopic(More)
Self-assembly refers to the spontaneous organization of individual building blocks into higher order structures. It occurs in biological systems such as spherical viruses, which utilize icosahedral symmetry as a guiding principle for the assembly of coat proteins into a capsid shell. In this study, we characterize the self-assembling protein nanoparticle(More)
Viruses with icosahedral capsids, which form the largest class of all viruses and contain a number of important human pathogens, can be modelled via suitable icosahedrally invariant finite subsets of icosahedral 3D quasicrystals. We combine concepts from the theory of 3D quasicrystals, and from the theory of structural phase transformations in crystalline(More)
For a significant number of viruses a structural transition of the protein container that encapsulates the viral genome forms an important part of the life cycle and is a prerequisite for the particle becoming infectious. Despite many recent efforts the mechanism of this process is still not fully understood, and a complete characterization of the expansion(More)
We introduce here a mathematical procedure for the structural classification of a specific class of self-assembling protein nanoparticles (SAPNs) that are used as a platform for repetitive antigen display systems. These SAPNs have distinctive geometries as a consequence of the fact that their peptide building blocks are formed from two linked coiled coils(More)
G. Indelicato1, P. Burkhard2,3 and R. Twarock4,5 1Dipartimento di Matematica, Università di Torino, Via Carlo Alberto 10, 10123 Torino, Italy 2The Institute of Materials Science, University of Connecticut, 97 North Eagleville Road, Storrs, CT 06269, USA 3Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269-3125, USA(More)
The authors investigated the effects of clonidine (alpha-2 stimulating agent) on blood glucose, insulin and glucagon levels in order to assess the alpha-adrenergic regulation of endocrine pancreatic secretion. Ten hypertensive female subjects affected with type 2 diabetes were studied; each subject was given a protein meal (boiled beef 200 g); blood samples(More)
A procedure for the construction and the classification of monoatomic multilattices in arbitrary dimension is developed. The algorithm allows one to determine the location of the points of all monoatomic multilattices with a given symmetry, or to determine whether two assigned multilattices are arithmetically equivalent. This approach is based on ideas from(More)