Giuliana Giribaldi

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Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis.

Patrizia D'Amelio, Anastasia Grimaldi, +7 authors Giancarlo Isaia
Bone
2008

Compelling evidences suggest that increased production of osteoclastogenic cytokines by activated T cells plays a relevant role in the bone loss induced by estrogen deficiency in the mouse. However,… (More)

Phagocytosis of Hemozoin Enhances Matrix

Valentina Gallo, Paolo Arese, Mauro Prato, Giuliana Giribaldi, Manuela Polimeni
2005

Involvement of inflammatory chemokines in survival of human monocytes fed with malarial pigment.

Giuliana Giribaldi, Mauro Prato, +7 authors Paolo Arese
Infection and immunity
2010

Hemozoin (HZ)-fed monocytes are exposed to strong oxidative stress, releasing large amounts of peroxidation derivatives with subsequent impairment of numerous functions and overproduction of… (More)

Analysis of changes in tyrosine and serine phosphorylation of red cell membrane proteins induced by P. falciparum growth.

Antonella Pantaleo, Emanuela Ferru, +6 authors Francesco M Turrini
Proteomics
2010

Phosphorylation of erythrocyte membrane proteins has been previously documented following infection and intracellular growth of the malarial parasite, Plasmodium falciparum in red cells. Much of this… (More)

Hemozoin- and 4-hydroxynonenal-mediated inhibition of erythropoiesis. Possible role in malarial dyserythropoiesis and anemia.

Giuliana Giribaldi, Daniela Ulliers, Evelin Schwarzer, Irene Roberts, Wanda Piacibello, Paolo Arese
Haematologica
2004

Malarial anemia involves destruction of parasitized and non-parasitized red blood cells and dyserythropoiesis. Malarial pigment, hemozoin (HZ), is possibly implicated in dyserythropoiesis. We show… (More)

Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-alpha production in human monocytes: role of matrix metalloproteinases in the pathogenesis of falciparum malaria.

Mauro Prato, Giuliana Giribaldi, Manuela Polimeni, Valentina Gallo, Paolo Arese
Journal of immunology
2005

Matrix metalloproteinase-9 (MMP-9), secreted by activated monocytes, degrades matrix proteins, disrupts basal lamina, and activates TNF-alpha from its precursors. In turn, TNF-alpha enhances… (More)

Role of the NF-κB transcription pathway in the haemozoin- and 15-HETE-mediated activation of matrix metalloproteinase-9 in human adherent monocytes.

Mauro Prato, Valentina Gallo, Giuliana Giribaldi, Elisabetta Aldieri, Paolo Arese
Cellular microbiology
2010

Haemozoin (HZ, malarial pigment) is a crystalline ferriprotoporphyrin IX polymer derived from undigested host haemoglobin haem, present in late stages of Plasmodium falciparum-parasitized RBCs and in… (More)

Co-ordinated stage-dependent enhancement of Plasmodium falciparum antioxidant enzymes and heat shock protein expression in parasites growing in oxidatively stressed or G6PD-deficient red blood cells

Oscar Bate Akide-Ndunge, Elisa Tambini, +4 authors Francesco M Turrini
Malaria Journal
2008

Plasmodium falciparum-parasitized red blood cells (RBCs) are equipped with protective antioxidant enzymes and heat shock proteins (HSPs). The latter are only considered to protect against thermal… (More)

Involvement of p38 MAPK in haemozoin-dependent MMP-9 enhancement in human monocytes.

Amina Khadjavi, Elena Valente, Giuliana Giribaldi, Mauro Prato
Cell biochemistry and function
2014

The lipid moiety of natural haemozoin (nHZ, malarial pigment) was previously shown to enhance expression and release of human monocyte matrix metalloproteinase-9 (MMP-9), and a major role for… (More)

Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing's sarcoma cell lines.

Cristina Zanini, Giuliana Giribaldi, +8 authors Francesco M Turrini
Journal of neurochemistry
2007

Neuroblastoma (NB) and Ewing's sarcoma (ES) represent the most common extracranial solid tumors of childhood. Heat shock proteins (HSP) are elevated in cancer cells and their over-expression was… (More)

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