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Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer
The analyses suggest that FOXB2 imposes a neuronal differentiation program on prostate cancer cells, which is associated with treatment failure and poor prognosis, and is a tissue-specific Wnt activator that promotes the malignant transformation of prostate cancer.
Wnt activator FOXB2 drives prostate cancer neuroendocrine differentiation
The results suggest that FOXB2 is a tissue-specific Wnt enhancer that promotes prostate cancer malignant transformation and decreases recurrence-free survival.
The oncogene FOXQ1 is a selective activator of Wnt/β-catenin signalling
It is reported that FOXQ1 is a bimodal transcriptional activator of Wnt target gene expression in normal and cancer cells and a novel component of the Wnt transcriptional complex that reinforces and specifies Wnt signalling in a context-dependent manner.