Giulia Colletta

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Rat thyroid cells in culture, rendered quiescent by hormone deprivation, can be stimulated to undergo DNA synthesis in the absence of serum by the addition of purified thyrotropin. The primary effect in response to thyrotropin action in thyroid cells is the induction of the c-fos oncogene, followed by c-myc expression. This suggests that thyrotropin acts as(More)
Familial adenomatous polyposis (FAP) is known to be associated with neoplasia of various tissues, including thyroid carcinoma. Germline mutations of the tumour-suppressor gene APC, responsible for the predisposition to FAP, may therefore be involved in the pathogenesis of these tumours. In this report the structure of the APC gene has been investigated in(More)
Fifty-one thyroid tumours and tumour-like lesions were analysed for instability at ten dinucleotide microsatellite loci and at two coding mononucleotide repeats within the transforming growth factor beta (TGF-beta) type II receptor (TbetaRII) and insulin-like growth factor II (IGF-II) receptor (IGFIIR) genes respectively. Microsatellite instability (MI) was(More)
TGF-beta1 is a potent inhibitor of growth and DNA synthesis in thyroid cells. It has also been shown that TGF-beta1 inhibits thyrocyte function. The functional inhibition is represented by a downregulation of thyroid specific genes, such as Na(+)/I(-) symporter (NIS), thyroglobulin (TG) and thyroperoxidase (TPO). The transcriptional control of these genes(More)
Amplification of erbB-2 gene and overexpression of gpl85erb""2 gene product is found in approximately one-third of primary human breast and ovarian cancer. Overexpression of gpI85erh"~2 was recently found in hu man papillary thyroid carcinomas, but not in thyroid follicular carcino mas or adenomas. The erbB-2 gene encodes a cell surface growth factor(More)
Transforming growth factor ß (TGF|8) is now known to have a number of effects other than inducing phenotypic transformation of fibroblastic cells: TGF/J controls proliferation, differentiation, and other functions in many cell types. In this paper we have analyzed the action of TGF/3, on a system of differentiated epithelial rat thyroid cells in culture(More)
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