Gislaine Zilli Réus

Suggest Changes
João Quevedo118
Helena Mendes Abelaira44
Emilio Luiz Streck40
Flavio Kapczinski40
Samira Silva Valvassori39
133João Quevedo
60Samira Silva Valvassori
50Emilio Luiz Streck
44Helena Mendes Abelaira
37Flavio Kapczinski

Filter Results:

  • Full text PDF available (11)

Publication Year

2006
2017

Publication Type

Co-author

Publication Venue

Brain Region

Cell Type

Key Phrases

Method

Organism

Learn More
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus.
Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the treatment of major depression. Considering that classic antidepressants may take long-lasting time to exhibit their main therapeutic effects, the present study aims to compare the… (More)
Chronic administration of ketamine elicits antidepressant-like effects in rats without affecting hippocampal brain-derived neurotrophic factor protein levels.
A growing body of evidence has pointed to the blockade of the N-methyl-d-aspartate (NMDA) receptor signaling as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the chronic treatment with ketamine and imipramine in rats. To this aim, rats were 14 days treated… (More)
Effects of chronic mild stress on the oxidative parameters in the rat brain.
Major depression is characterized for symptoms at the psychological, behavioral and physiological levels. The chronic mild stress model has been used as an animal model of depression. The consumption of sweet food, locomotor activity, body weight, lipid and protein oxidation levels and superoxide dismutase and catalase activities in the rat hippocampus,… (More)
Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania.
OBJECTIVE Previous studies have suggested that oxidative stress may play a role in the pathophysiology of bipolar disorder (BD). Moreover, recent studies indicate that lithium and valproate exert neuroprotective effects against oxidative stress. We studied the effects of the mood stabilizers lithium and valproate on amphetamine-induced oxidative stress in… (More)
Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain.
A growing body of evidence has pointed to the N-methyl-d-aspartate (NMDA) receptor antagonists as a potential therapeutic target for the treatment of major depression. The present study investigated the possibility of synergistic interactions between antidepressant imipramine with the uncompetitive NMDA receptor antagonist ketamine. Wistar rats were acutely… (More)
Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm.
Major depression is a common, serious and recurrent disorder, characterized by symptoms at the psychological, behavioral and physiological levels. Recent studies have suggested that reactive oxygen species (ROS) may play a role in the pathophysiology of bipolar disorder. The chronic mild stress (CMS) rat model has been used as an animal model of depression,… (More)
The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain.
Recently, several studies have emerged suggesting a role of the intracellular survival pathways in the treatment of mood disorders. In addition, the beneficial effects of using a combination of antipsychotics and antidepressants have been shown. With this in mind, we evaluated the effects of the acute administration of fluoxetine (FLX), olanzapine (OLZ) and… (More)
Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania.
There is an emerging body of data suggesting that mood disorders are associated with decreased brain-derived neurotrophic factor (BDNF). The present study aims to investigate the effects of the mood stabilizers lithium (Li) and valproate (VPT) in an animal model of bipolar disorder. In the first experiment (acute treatment), rats were administered… (More)
Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats.
Several studies have supported the idea that ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) is an important player in the etiology of psychopathologies, such as anxiety disorders and major depression. Additionally, studies have shown that ketamine induces antidepressant effects in humans as well as in rodents subjected to animal models of… (More)
Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?
A growing body of evidence has pointed to the NMDA receptor antagonists as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural and molecular effects of the acute and chronic treatment with memantine and imipramine in rats. To this aim, rats were acutely or chronically for 14 days once a… (More)