Gislaine Zilli Réus

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Effects of lithium and valproate on amphetamine-induced oxidative stress generation in an animal model of mania.

Benicio N. Frey, Samira S Valvassori, +6 authors João Quevedo
Journal of psychiatry & neuroscience : JPN
2006

OBJECTIVE Previous studies have suggested that oxidative stress may play a role in the pathophysiology of bipolar disorder (BD). Moreover, recent studies indicate that lithium and valproate exert… (More)

Effects of mood stabilizers on hippocampus BDNF levels in an animal model of mania.

Benicio N. Frey, Ana C Andreazza, +5 authors Flávio Kapczinski
Life sciences
2006

There is an emerging body of data suggesting that mood disorders are associated with decreased brain-derived neurotrophic factor (BDNF). The present study aims to investigate the effects of the mood… (More)

Changes in Antioxidant Defense Enzymes after d-amphetamine Exposure: Implications as an Animal Model of Mania

Benicio N. Frey, Samira S Valvassori, +6 authors João Quevedo
Neurochemical Research
2006

Studies have demonstrated that oxidative stress is associated with amphetamine-induced neurotoxicity, but little is known about the adaptations of antioxidant enzymes in the brain after amphetamine… (More)

Ketamine plus imipramine treatment induces antidepressant-like behavior and increases CREB and BDNF protein levels and PKA and PKC phosphorylation in rat brain

Gislaine Zilli Réus, Roberto Buss Stringari, +5 authors João Quevedo
Behavioural Brain Research
2011

A growing body of evidence has pointed to the N-methyl-d-aspartate (NMDA) receptor antagonists as a potential therapeutic target for the treatment of major depression. The present study investigated… (More)

Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus

Lêda S. B. Garcia, Clarissa Martinelli Comim, Samira S Valvassori, Gislaine Zilli Réus, João Quevedo
Progress in Neuro-Psychopharmacology and…
2008

Ketamine is a non-competitive antagonist to the phencyclidine site of N-methyl-d-aspartate (NMDA) receptor. Clinical findings point to a rapid onset of action for ketamine on the treatment of major… (More)

Ketamine treatment reverses behavioral and physiological alterations induced by chronic mild stress in rats

Lêda S. B. Garcia, Clarissa Martinelli Comim, Samira S Valvassori, Gislaine Zilli Réus, João Quevedo
Progress in Neuro-Psychopharmacology and…
2009

Several studies have supported the idea that ionotropic glutamate N-methyl-d-aspartate receptor (NMDA) is an important player in the etiology of psychopathologies, such as anxiety disorders and major… (More)

The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders

Gislaine Zilli Réus, Gabriel Rodrigo Fries, +5 authors João Quevedo
Neuroscience
2015

Psychiatric disorders, including major depressive disorder (MDD), bipolar disorder (BD) and schizophrenia, affect a significant percentage of the world population. These disorders are associated with… (More)

Effects of chronic mild stress on the oxidative parameters in the rat brain

Giancarlo Lucca, Clarissa Martinelli Comim, +6 authors João Quevedo
Neurochemistry International
2009

Major depression is characterized for symptoms at the psychological, behavioral and physiological levels. The chronic mild stress model has been used as an animal model of depression. The consumption… (More)

Increased oxidative stress in submitochondrial particles into the brain of rats submitted to the chronic mild stress paradigm.

Giancarlo Lucca, Clarissa Martinelli Comim, +6 authors João Quevedo
Journal of psychiatric research
2009

Major depression is a common, serious and recurrent disorder, characterized by symptoms at the psychological, behavioral and physiological levels. Recent studies have suggested that reactive oxygen… (More)

Neurochemical and behavioural effects of acute and chronic memantine administration in rats: Further support for NMDA as a new pharmacological target for the treatment of depression?

Gislaine Zilli Réus, Roberto Buss Stringari, +4 authors João Quevedo
Brain Research Bulletin
2010

A growing body of evidence has pointed to the NMDA receptor antagonists as a potential therapeutic target for the treatment of major depression. The present study was aimed to evaluate behavioural… (More)

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