Gislaine Vissoky Cé

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Macro and microvascular disease are the main cause of morbi-mortality in type 1 diabetes (T1DM). Although there is a clear association between endothelial dysfunction and atherosclerosis in type 2 diabetes, a cause-effect relationship is less clear in T1DM. Although endothelial dysfunction (ED) precedes atherosclerosis, it is not clear weather, in recent(More)
This article will provide the necessary information to establish a childhood and adolescence management center that would promote the integration and coordination of interdisciplinary members as healthcare teams. It will also show how Instituto da Criança com Diabetes from Rio Grande do Sul (ICD) was built, structured and how it works. The aim of this(More)
OBJECTIVES To evaluate prospectively the efficacy and safety of insulin glargine use for the metabolic control of type 1 diabetes mellitus (T1DM) children younger than eight years old. METHODS Nineteen boys and 11 girls with T1DM were included. Before initiating insulin glargine, all children received intensive NPH and aspart insulins for three months.(More)
CONTEXT The relation between endothelial dysfunction (ED), glycemic control, and early type I diabetes mellitus (T1DM) is unclear. OBJECTIVE The objective of the study was to evaluate the association of ED, glycemic control, and the duration of diabetes in T1DM. DESIGN This was a cross-sectional study. SETTING The study was conducted at a public(More)
Background Long-term type 1 diabetes (T1D) is associated to microvascular complications. In a previous study of our group, we observed that endothelial dysfunction (ED) was present in half of adolescents under 5 yrs. of T1D duration, even before the onset of microvascular disease. Although ED is associated to vascular complications, the natural history and(More)
Vascular complications are the main cause of mortality and morbidity in diabetes. Mechanisms involved in the development of micro and macrovascular disease are complex and partially understood, but invariably begin as a dysfunctional endothelium. Nitric oxide is an important regulator of endothelial function and the impairment of its activity is determinant(More)
Material and methods The study enrolled 65 subjects diagnosed as T2D up to 21 yrs. of age from a cohort that began in 2004 in a reference center. A cross-sectional study was conducted to obtain clinical and laboratory data from chart reviews. Body mass index (BMI) was defined according to World Health Organization (WHO) or National Center for Health(More)
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