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Urease Inhibitors of Agricultural Interest Inspired by Structures of Plant Phenolic Aldehydes
The plant phenolic natural products (PNPs) protocatechuic aldehyde, syringaldehyde and vanillin were used as platforms for obtaining four urease inhibitors. Urea (urease substrate) or thioureaExpand
β-lactam antibiotics: An overview from a medicinal chemistry perspective.
TLDR
The different classes of beta-lactam antibiotics (penicillins, cephalosporins, carbapenems, monobactams and penems) are discussed in light of their stability, sensitivity to β- lactamases, mechanism of action and spectrum of antimicrobial activity. Expand
Synthesis of new lophine-carbohydrate hybrids as cholinesterase inhibitors: cytotoxicity evaluation and molecular modeling.
TLDR
In this study, nine novel hybrids derived from d-xylose, d-ribose, and d-galactose sugars connected by a methylene chain with lophine were synthesized by a four-component reaction to afford the substituted imidazole moiety and formed a T-stacking interaction with Trp231, a residue accessible exclusively in the BuChE cavity. Expand
Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies.
Phosphodiesterase 4 (PDE4) inhibitors have emerged as a new strategy to treat asthma and other lung inflammatory diseases. Searching for new PDE4 inhibitors, we previously reported the discover ofExpand