Gisela Wohlleben

Learn More
Most infections with respiratory viruses induce Th1 responses characterized by the generation of Th1 and CD8(+) T cells secreting IFN-gamma, which in turn have been shown to inhibit the development of Th2 cells. Therefore, it could be expected that respiratory viral infections mediate protection against asthma. However, the opposite seems to be true,(More)
Exposure to common environmental antigens (Ags) can lead to atopic disorders, such as allergic asthma, hay fever, eczema and allergic rhinitis, which affect up to 20% of the population in developed countries. Although it is still not understood why exposure to allergen causes atopic disorders in some individuals but not others, it is clear that it involves(More)
BACKGROUND Tumor hypoxia is a known risk factor for reduced response to radiotherapy. The evaluation of noninvasive methods for the detection of hypoxia is therefore of interest. Osteopontin (OPN) has been discussed as an endogenous hypoxia biomarker. It is overexpressed in many cancers and is involved in tumor progression and metastasis. METHODS To(More)
BACKGROUND In head and neck cancer little is known about the kinetics of osteopontin (OPN) expression after tumor resection. In this study we evaluated the time course of OPN plasma levels before and after surgery. METHODS Between 2011 and 2013 41 consecutive head and neck cancer patients were enrolled in a prospective study (group A). At different time(More)
  • 1