Girish Sindhwani

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BACKGROUND In view of the role of TLR2 activation in host defense against mycobacteria, the present study was conducted to examine whether TLR2 polymorphisms could account for the increased prevalence of tuberculosis in Indian patients. Detection of such polymorphisms would help in assessing the risk of developing active tuberculosis among contacts or HIV(More)
Tobacco smoking as a risk factor for tuberculosis (TB) is often ignored. This study was carried out to study tobacco smoking-associated risk for tuberculosis. Ninety-five patients with TB, admitted in the Himalayan Institute Hospital, Dehradun, India and 190 controls were randomly selected and questioned regarding their smoking status and type, quantity and(More)
BACKGROUND Central airway obstruction (CAO) due to malignant and benign conditions is common. Tumour ablation by various techniques helps effective palliation of symptoms in such patients. Tumour ablation using endobronchial electrocautery (EBEC) with flexible bronchoscope (FB) is an established procedure. However, there is paucity of data from India on(More)
INTRODUCTION The Revised National Tuberculosis Control Program (RNTCP) aims to achieve detection of 70% of new smear-positive patients in a community and to cure 85% of such patients. Though an elaborate recording and reporting system is in place to monitor the success of the program, no record of patients who do not complete the diagnostic process is(More)
BACKGROUND AND OBJECTIVE This study was undertaken to assess the feasibility of diagnosing pulmonary tuberculosis (PTB) by collecting two sputum samples on a single day (1-day protocol), and to compare this protocol with the national policy of collecting two samples on consecutive days (2-day protocol). METHODS A total of 513 individuals with cough that(More)
INTRODUCTION Pulmonary rehabilitation is now an accepted modality of care in the management of chronic obstructive pulmonary disease (COPD) patients. However, in resource-limited settings, conventional pulmonary rehabilitation may not be feasible due to the high cost involved and the extensive infrastructure requirement. In view of these constraints, we(More)
AIM This study was conducted to assess the role of cytology in the diagnosis of lung lesions and to compare it with histopathology. It was also intended to evaluate the role of rapid on site evaluation (ROSE) as an adjunct to cytological diagnosis of lung lesions. MATERIALS AND METHODS The study included all the cases of lung lesions, which were diagnosed(More)
BACKGROUND AND OBJECTIVES Mechanical ventilation is the recommended treatment in unconscious patients with acute exacerbation of chronic obstructive pulmonary disease (COPD) and hypercapenic respiratory failure. But, in resource-poor countries, many of these patients are not able to afford this treatment due to financial constraints. The main aim of this(More)
BACKGROUND We screened patients with chronic respiratory diseases for microbiological and serological evidences of fungal colonisation; in order to determine its prevalence in this group of patients, examine potential clinical and radiological predictors of fungal colonisation and characterise fungal agents associated with individual diseases. METHODS BAL(More)
SETTING Patients of pulmonary tuberculosis (TB) attending the out and in patient department of pulmonary medicine, Himalayan Institute of Medical Sciences (HIMS), a post graduate institute and a large tertiary care center in Dehradun. OBJECTIVE To compare the clinico-radiological pattern of pulmonary tuberculosis in the young adult (18-59 years) and(More)