Girish Sindhwani

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In view of the role of TLR2 activation in host defense against mycobacteria, the present study was conducted to examine whether TLR2 polymorphisms could account for the increased prevalence of tuberculosis in Indian patients. Detection of such polymorphisms would help in assessing the risk of developing active tuberculosis among contacts or HIV positive(More)
BACKGROUND Lung cancer is one of the most aggressive and prevalent type of malignancy causing high morbidity and mortality. Tobacco smoking continues to be the leading cause of lung cancer worldwide. An increasing incidence of lung cancer has been observed in India. OBJECTIVE The aim of this study was to evaluate the clinico, a pathological profile of the(More)
We screened patients with chronic respiratory diseases for microbiological and serological evidences of fungal colonisation; in order to determine its prevalence in this group of patients, examine potential clinical and radiological predictors of fungal colonisation and characterise fungal agents associated with individual diseases. BAL samples from 60(More)
AIM This study was conducted to assess the role of cytology in the diagnosis of lung lesions and to compare it with histopathology. It was also intended to evaluate the role of rapid on site evaluation (ROSE) as an adjunct to cytological diagnosis of lung lesions. MATERIALS AND METHODS The study included all the cases of lung lesions, which were diagnosed(More)
BACKGROUND/AIM To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs. MATERIALS AND METHODS Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were subjected to culture and sensitivity testing against common antitubercular drugs. RESULT Growth of(More)
SETTING Patients of pulmonary tuberculosis (TB) attending the out and in patient department of pulmonary medicine, Himalayan Institute of Medical Sciences (HIMS), a post graduate institute and a large tertiary care center in Dehradun. OBJECTIVE To compare the clinico-radiological pattern of pulmonary tuberculosis in the young adult (18-59 years) and(More)
BACKGROUND Diffuse parenchymal lung diseases (DPLD) are a group of disorders characterized by chest radiological findings of bilateral diffuse shadowing. Lung biopsy is generally required to make an etiological diagnosis of DPLD's. Transbronchial lung biopsy (TBLB) is a minimally invasive method to achieve a lung sample which has been found to be a useful(More)
INTRODUCTION Pulmonary rehabilitation is now an accepted modality of care in the management of chronic obstructive pulmonary disease (COPD) patients. However, in resource-limited settings, conventional pulmonary rehabilitation may not be feasible due to the high cost involved and the extensive infrastructure requirement. In view of these constraints, we(More)
BACKGROUND Spontaneous pneumothorax occurs subsequent to a disruption in the continuity of visceral pleura and escape of air into pleural space. It is usually difficult, sometimes impossible to detect evidence of pulmonary pathology by clinical or conventional radiographic methods. Computed tomography provides additional informations not obtainable with(More)
BACKGROUND AND OBJECTIVE This study was undertaken to assess the feasibility of diagnosing pulmonary tuberculosis (PTB) by collecting two sputum samples on a single day (1-day protocol), and to compare this protocol with the national policy of collecting two samples on consecutive days (2-day protocol). METHODS A total of 513 individuals with cough that(More)