Girija Kuttan

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BACKGROUND Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells. METHODS B16F-10 melanoma cells were treated in the presence and absence of harmine in vitro. Morphological(More)
Although reports on the efficacy of homeopathic medicines in animal models are limited, there are even fewer reports on the in vitro action of these dynamized preparations. We have evaluated the cytotoxic activity of 30C and 200C potencies of ten dynamized medicines against Dalton's Lymphoma Ascites, Ehrlich's Ascites Carcinoma, lung fibroblast (L929) and(More)
The role of abrin, a toxic lectin isolated from seeds of Abrus precatorius Linn in inducing apoptosis in murine Dalton's Lymphoma Ascites (DLA) cells was evaluated. Abrin when incubated at the concentration of 10 ng per million DLA cells could bring about cell death as typical morphological changes with apoptosis. However, necrotic cell death dominated when(More)
Sidha medicines which are popular in Southern parts of India have significant quantity of heavy metals. It is claimed that mode of preparation of these drugs reduces their toxicities. However toxicity studies of Sidha preparations are seldom carried out. In the present study we have evaluated toxicity of Rasagandhi Mezhugu (RM), a Sidha preparation in(More)
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