Giovanni Ucci

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Anemia is frequently associated with cancer due to the disease itself and antineoplastic treatments. This open-label, uncontrolled, multi-center study evaluated the effects of once-weekly (qw) epoetin alfa 40,000 IU on hemoglobin (Hb) levels and quality of life (QoL) in anemic patients receiving chemotherapy for solid tumors. A total of 522 patients with Hb(More)
In many cell systems, resistance to cytotoxic drugs is acquired by the amplification and/or overexpression of the multidrug resistance (mdr) gene, which codes for the glycoprotein, p170 (P-glycoprotein). Moreover, in a variety of malignant tumours there is increasing evidence of the relationship between the DNA ploidy pattern of patients and their(More)
OBJECTIVES In 2005, the National Health Service recommended a population-based colorectal cancer (CRC) screening program using biennial fecal occult blood testing (FOBT), followed by total colonoscopy in positive patients. So far, no studies have been performed to evaluate the impact of a mass-screening CRC campaign on the health system services at the(More)
BACKGROUND The results of a pilot colorectal cancer screening programme by biennial immunochemical faecal occult blood test (FOBT) are reported. METHODS All residents aged between 50 and 69 years in the Italian province of Lecco were invited to have a FOBT. Those with a positive result were offered colonoscopy. FOBT uptake and compliance with colonoscopy(More)
BACKGROUND The fast growing demand and the shortage of resources are pushing toward more efficient models of survivorship care delivery. The Associazione Italiana di Oncologia Medica (AIOM) established an interdisciplinary working group with the purpose of promoting organizational improvements at the national level. A survey aimed at assessing attitudes and(More)
1580 Background: Mass screening programs for colorectal cancer are based on fecal occult blood test (FOBT). To improve its low sensitivity other fecal tests such as tumor M2-PK or fecal calprotectin have been studied with conflicting results. METHODS We tested an innovative combination of fecal tests (immunochemical FOBT, tumor M2-PK and calprotectin) as(More)
A subgroup analysis comparing elderly (age > or =70 years; n=95) with younger (age <70 years; n=390) patients was performed on data from a prospective, multicenter, open-label study assessing the effects of once-weekly epoetin alfa 40,000 International Units (IU) for 16-20 weeks on hemoglobin (Hb) levels and quality of life (QoL) in anemic adult patients(More)
One of the priorities of personalized medicine regards the role of early integration of palliative care with cancer-directed treatments, called simultaneous care. This article, written by the Italian Association of Medical Oncology (AIOM) Simultaneous and Continuous Care Task Force, represents the position of Italian medical oncologists about simultaneous(More)
Bromodeoxyuridine (BrdUrd) is a pyrimidine analogue which is incor porated into the DN A of proliferating cells. When in vivoBrdUrd infusion is coupled with Divariate flow cytomctry to measure cell BrdUrd incor poration and I)V\ content, both the percentage of DNA-synthesizing cells jBrdUrd-labeling index (LI)] and the DNA synthesis time (Ts) can be(More)