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Ontogenesis of T cells in the thymus is a complex process whose molecular control is poorly understood. The present study investigated microRNAs involved in human thymocyte differentiation by comparing the microRNA expression profiles of thymocytes at the double-positive, single-positive CD4(+) and single-positive CD8(+) maturation stages. Microarray(More)
This paper presents the latest results in developing an anthropomorphic dextrous hand for a 2-years-old humanoid. As this robot is aimed to be a physical platform for cognition, the number of degrees of freedom of the upper part of the body has been maximized. The robotic hand has 20 DoFs and 9 motors to accomplish optimal grasping and manipulation. Based(More)
This paper presents a research initiative on embodied cognition called RobotCub. RobotCub is an EU-funded project that aims at developing an open humanoid robotic platform and, simultaneously, following an original research path in synthetic cognition. We report on the motivations behind the realization of our humanoid robotic platform and the current(More)
This paper presents first results in developing an anthropomorphic dexterous hand for a 2-years-old humanoid. As this robot is aimed to be a physical platform for cognition, the number of degrees of freedom of the upper part of the body has been maximized. The robotic hand has 20 DoFs and 9 motors to accomplish optimal grasping and manipulation. Based on(More)
This paper presents recent results aimed at developing a functional prosthetic hand characterized by an EMG-control and by a simple and low cost fabrication technology. In order to overcome some limitations of current prosthetic hands mainly related to the poor functionality and controllability, the prosthetic hand has been designed following a(More)
In this paper, some recent results about the experimental trials we are performing on a functional prosthetic hand characterized by an EMG-control and by a simple and low cost fabrication technology are shown. The innovation described in this paper is the fabrication of a compliant under-actuated prosthetic hand. The structure of the hand (both palm and(More)
The paper presents a controller for a multi-fingered underactuated prosthetic hand based on tendon transmission. The control architecture is implemented in two subsequent and different phases. The first one is the pre-shaping of the hand, based on the grasp type is implemented by stand-alone motion controllers using PID position control algorithms. The(More)
BACKGROUND Scimitar syndrome is a rare congenital heart disease. To evaluate the surgical results, we embarked on the European Congenital Heart Surgeons Association (ECHSA) multicentric study. METHODS AND RESULTS From January 1997 to December 2007, we collected data on 68 patients who underwent surgery for scimitar syndrome. Primary outcomes included(More)
OBJECTIVES Outcomes evaluation is enhanced by assignment of operative procedures to appropriate categories based upon relative average risk. Formal risk modelling is challenging when a large number of operation types exist, including relatively rare procedures. Complexity stratification provides an alternative methodology. We report the initial application(More)
Adrenomedullin (AM) is a multifunctional peptide endowed with various biological actions mediated by the interaction with the calcitonin receptor-like receptor (CLR), which couples to the receptor activity-modifying proteins 2 or 3 (RAMP2 or RAMP3) to form the functional plasma membrane receptors AM1 and AM2, respectively. In this study, we investigated for(More)