Giovanni Parinello

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AIMS The anti-anginal agent ivabradine slows heart rate (HR) by selectively inhibiting the I(f) current in the sinus node. We report an ex vivo study to evaluate the anti-ischaemic effect of ivabradine in terms of modulation of cardiac energy metabolism. METHODS AND RESULTS A Langendorff-perfused rabbit heart model was subjected to low-flow ischaemia and(More)
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