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BACKGROUND This randomised phase III study investigated if in responsive and stable disease (SD) stage IV patients after two courses of cisplatin and gemcitabine, single-agent gemcitabine (experimental arm) was not inferior in terms of overall survival (OS) to cisplatin-gemcitabine (standard arm). PATIENTS AND METHODS Noninferiority was defined as an(More)
A growing amount of digital objects is designated for long term preservation-a time scale during which technologies, formats and communities are very likely to change. Specialized approaches, models and technologies are needed to guarantee the long-term understandability of the preserved data. Maintaining the authenticity (trustworthiness) and provenance(More)
Cisplatin-based combinations are efficacious in increasing the overall survival of patients with non-small cell lung cancer (NSCLC), but their toxicity makes them unsuitable for elderly and unfit patients. The primary objective of this non-randomized phase II study was to evaluate the feasibility and activity of the gemcitabine plus vinorelbine combination(More)
Trust is at stake in the digital environment. Records stored and managed in the cloud cannot be trusted using the same approach and tools of the past. The Preservation as a Service for Trust (PaaST) is a research project on digital preservation aiming at creating a model for preserving digital records in the cloud while maintaining their authenticity. The(More)
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