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Vasoactive intestinal peptide (VIP) is a vasorelaxant peptide that addresses two receptor subtypes, VPAC1 and VPAC2. It stimulates insulin secretion and mediates anti-inflammatory effects and has been proposed for treatment of type 2 and autoimmune diabetes. In the heart, VIP is produced and released primarily by intrinsic neurons and improves cardiac(More)
Neuronal nicotinic acetylcholine receptors (nAChRs) play an essential role in immunomodulation of macrophages. In particular, the alpha7 subunit confers inhibition of the systemic inflammatory response to bacterial lipopolysaccharide, thereby being the crucial element of the cholinergic anti-inflammatory pathway (Borovikova et al., 2000; Pavlov et al.,(More)
Previous studies have shown that ryanodine in low concentrations and caffeine increase intracellular [Ca(2+)] in the absence of external Ca(2+), suggesting Ca(2+) release from intracellular stores through ryanodine receptors (RyR). In the present study we employed amperometry to examine the effect of RyR agonists and antagonists on serotonin release(More)
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