Giovanni Francesco Pellicanò

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BACKGROUND Atazanavir (ATV) has demonstrated high efficacy and safety in both treatment-naïve and treatment-experienced patients. Some comparative data are available on the durability of ritonavir-boosted (ATV/r) and unboosted formulations, but there are no data on clinicians' motivations for choosing one or another in everyday practice. The aim of this(More)
BACKGROUND Long term efficacy of raltegravir (RAL)-including regimens in highly pre-treated HIV-1-infected patients has been demonstrated in registration trials. However, few studies have assessed durability in routine clinical settings. METHODS Antiretroviral treatment-experienced patients initiating a RAL-containing salvage regimen were enrolled.(More)
Purpose of the study To further investigate CPK increases and muscle symptoms in a cohort of HIV-infected patients receiving ral-tegravir-based HAART compared with a control cohort with similar characteristics receiving darunavir-based HAART. Methods The SCOLTA Project is a prospective, observational, multicenter study created to assess the incidence of(More)
Apart from the BENCHMRK study, there are no large observational experiences describing the long-term efficacy and safety of rescue regimens for human immunodeficiency virus type 1 (HIV-1) infection. Antiretroviral-experienced patients with detectable viraemia starting a raltegravir (RAL)-based regimen between March 2007 and June 2009 were consecutively(More)
The HIV-induced demise of CD4-T cells is thought to be a result of the execution of genetically programmed cell death that occurs in lymphoid tissue, where many resident T cells are chronically hyperactivated. Since HIV-induced alterations of cell cycle control has been often indicated as prominent mechanism of immune hyper activation and cause of apoptotic(More)
T cells reactive to self-antigens are present in the peripheral blood of patients with autoimmune diseases as well as in healthy subjects. Although T cell-response to the self-myelin antigen myelin basic protein (MBP) has been widely investigated in multiple sclerosis (MS) patients, very little is known about the evolution over time of this response and its(More)
INTRODUCTION Anxiety disorders are frequent in HIV-infected individuals, can pre-exist or occur during HIV infection. We evaluated with a self-reported questionnaire whether anxiety is related to HIV clinical status and therapeutic success in a cohort of HIV-positive subjects in Sicily. PATIENTS AND METHODS We enrolled 251 patients on combination(More)
Purpose of the study Sexual dysfunctions (SD) in HIV-1 infected individuals have been associated with infection, modification of body image and HAART, mainly PI based treatment. Anxiety is common in HIV+ subjects. We hypothesized that anxiety could be a cofactor of SDs. A cross sectional analysis was conducted in a cohort of 109 HIV+ males with at least 6(More)