Giovanni Dothel

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The debate about the ethical and scientific issues regarding the use of animals in research is mainly focused on these questions: a) whether preclinical studies in animals are still ethically acceptable; b) whether it is possible to establish more soundly their predictivity; c) what measures should be taken to reduce the clinical attrition often due to(More)
Visceral hypersensitivity is currently considered a key pathophysiological mechanism involved in pain perception in large subgroups of patients with functional gastrointestinal disorders, including irritable bowel syndrome (IBS). In IBS, visceral hypersensitivity has been described in 20%-90% of patients. The contribution of the central nervous system and(More)
BACKGROUND & AIMS Mediators released by the intestinal mucosa of patients with irritable bowel syndrome (IBS) affect the function of enteric and extrinsic sensory nerves, which can contribute to the development of symptoms. Little is known about the effects of mucosal mediators on intestinal neuroplasticity. We investigated how these mediators affect the(More)
BACKGROUND Mediators released in the mucosal milieu have been suggested to be involved in visceral hypersensitivity and abdominal pain in patients with irritable bowel syndrome (IBS). However, their impact on myenteric neurons remains unsettled. METHODS Mucosal biopsies were obtained from the descending colon of patients with IBS and controls. Mucosal(More)
Unfolding | Clusters is a music and visual media installation modeled from published scientific data related to the pathophysiology of amyotrophic lateral sclerosis (ALS). The work aims to create an engaging multimodal experience useful for raising awareness in the greater public about the disease and its scientific process. This paper describes the(More)
Unfolding | Clusters is a music and visual media installation modelled from published scientific data related to the pathophysiology of amyotrophic lateral sclerosis (ALS), with a focus on biomolecular processes related to the Superoxide Dismutase-1 (SOD1) protein mutation and misfolding. ALS (also referred to as Motor Neurone Disease) is a rare(More)
Amyotrophic lateral sclerosis (ALS), also referred to as Motor Neurone Disease in the UK, is the most common of the five motor neuron diseases. Communicating about the behaviour of ALS with a wider audience remains one of the main goals of charities and associated organisations driving medical research and providing care for sufferers of ALS. This work(More)
The past decade has witnessed an outstanding scientific production focused towards the possible clinical applications of mesenchymal stromal cells (MSCs) in autoimmune and chronic inflammatory diseases. This raised the need of novel standards to adequately address quality, efficacy and safety issues of this advanced therapy. The development of a streamlined(More)
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