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BACKGROUND Estimates of global DNA methylation from repetitive DNA elements, such as Alu and LINE-1, have been increasingly used in epidemiological investigations because of their relative low-cost, high-throughput and quantitative results. Nevertheless, determinants of these methylation measures in healthy individuals are still largely unknown. The aim of(More)
Based on the idea that electric light at night might account for a portion of the high and rising risk of breast cancer worldwide, it was predicted long ago that women working a non-day shift would be at higher risk compared with day-working women. This hypothesis has been extended more recently to prostate cancer. On the basis of limited human evidence and(More)
to yield nutritional standards. Voit and Atwater produced them by observing the food eaten by groups or by popula tions considered to be healthy. This same approach contin ues to be productive today, as is shown clearly by a prior symposium (1). Like most algebraic approaches, epidemiology makes a minimum of assumptions and is therefore likely to contain a(More)
The impact of shift and night work on health shows a high inter- and intra-individual variability, both in terms of kind of troubles and temporal occurrence, related to various intervening factors dealing with individual characteristics, lifestyles, work demands, company organisation, family relations and social conditions. The way we define "health" and(More)
In this paper we use a search and matching model to investigate the economic relationship between training and local economic conditions. We identify two aspects of this relationship going in opposite directions: on the one hand, the complementarity between local knowledge spillovers and training generates a positive correlation between training and local(More)
  • G Costa
  • 2000
The paper summarises some studies carried out in recent years on Italian air traffic controllers. Work stress appeared related mainly to mental charge, aggravated by time pressure and high responsibility. Shiftwork was not considered highly stressful, thanks to the good shift schedules adopted. The disorders most frequently complained of had a prevalent(More)