Giovanni Butturini

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BACKGROUND Postoperative pancreatic fistula (POPF) is still regarded as a major complication. The incidence of POPF varies greatly in different reports, depending on the definition applied at each surgical center. Our aim was to agree upon an objective and internationally accepted definition to allow comparison of different surgical experiences. METHODS(More)
BACKGROUND The ideal closure technique of the pancreas after distal pancreatectomy is unknown. We postulated that standardised closure with a stapler device would prevent pancreatic fistula more effectively than would a hand-sewn closure of the remnant. METHODS This multicentre, randomised, controlled, parallel group-sequential superiority trial was done(More)
CONTEXT Adjuvant fluorouracil has been shown to be of benefit for patients with resected pancreatic cancer. Gemcitabine is known to be the most effective agent in advanced disease as well as an effective agent in patients with resected pancreatic cancer. OBJECTIVE To determine whether fluorouracil or gemcitabine is superior in terms of overall survival as(More)
BACKGROUND Anastomotic failure is still a significant problem that affects the outcome of pancreaticoduodenectomy. There have been many techniques proposed for the reconstruction of pancreatic digestive continuity, but there have been few prospective and randomized studies that compare their efficacy. METHODS In the current work, 144 patients who(More)
BACKGROUND AND AIMS:Chronic pancreatitis (CP) produces disabling symptoms and requires major clinical interventions over a number of years. There is consensus that quality-of-life (QoL) assessment should be part of assessing the treatment and outcome of CP. These symptoms and treatments resemble those of pancreatic cancer, for which there are validated QoL(More)
OBJECTIVE To describe the clinical characteristics, indications, technical procedures, and outcome of a consecutive series of laparoscopic distal pancreatic resections performed by the same surgical team. SUMMARY BACKGROUND DATA Laparoscopic distal pancreatic resection has increasingly been described as a feasible and safe procedure, although accompanied(More)
BACKGROUND Standard resections for benign and borderline neoplasms of the pancreas are associated with a significant risk of long-term functional impairment, whereas enucleation preserves healthy parenchyma and pancreatic function. The aim of this study was to evaluate postoperative and long-term oncological and functional results after pancreatic(More)
BACKGROUND Pancreatic metastases from renal cell carcinoma are rare but highly resectable. The aim of this study was to review a series of patients with this condition. METHODS The study involved 22 consecutive patients with histologically proven pancreatic metastases from renal cell cancer. RESULTS Seventeen of the 22 patients had surgery. No patient(More)
BACKGROUND The correlation of the amylase value in drains (AVD) with the development of pancreatic fistula (PF) is still unclear. AIM The purpose of this study was to identify within the first postoperative day (POD1) the predictive role of different risks factors, including AVD, in the development of PF. PATIENTS AND METHODS We prospectively(More)
SUMMARY OF BACKGROUND DATA The role of surgically placed intra-abdominal drainages after pancreatic resections has not been clearly established. In particular, their effect on morbidity rates and the optimal timing for their removal remains controversial. METHODS A total of 114 eligible patients who underwent standard pancreatic resections and at low risk(More)