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Role of brain allopregnanolone in the plasticity of gamma-aminobutyric acid type A receptor in rat brain during pregnancy and after delivery.

• A Concas, Maria Cristina Mostallino, +6 authors Giovanni Biggio
• Proceedings of the National Academy of Sciences…
• 1998

The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma-aminobutyric acid type A (GABAA) receptors in the brain during pregnancy and… (More)

Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet.

• Giovanni Biggio, Fabio Fadda, P Fanni, Alessandro Tagliamonte, Gian Luigi Gessa
• Life sciences
• 1974

Social isolation-induced decreases in both the abundance of neuroactive steroids and GABA(A) receptor function in rat brain.

• Mariangela Serra, Maria Giuseppina Pisu, +6 authors Giovanni Biggio
• Journal of neurochemistry
• 2000

The effects of social isolation on behavior, neuroactive steroid concentrations, and GABA(A) receptor function were investigated in rats. Animals isolated for 30 days immediately after weaning… (More)

Time-dependent changes in rat brain neuroactive steroid concentrations and GABAA receptor function after acute stress.

• Maria Luisa Barbaccia, Gianna Roscetti, +4 authors Giovanni Biggio
• Neuroendocrinology
• 1996

The time courses of changes in rat brain neuroactive steroid concentrations and gamma-aminobutyric acid type A (GABAA) receptor function elicited by acute stress were investigated in animals exposed… (More)

Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus.

• Enrico Sanna, Giuseppe Talani, +4 authors Giovanni Biggio
• The Journal of neuroscience : the official…
• 2004

An interaction with the GABA type A (GABA(A)) receptor has long been recognized as one of the main neurochemical mechanisms underlying many of the pharmacological actions of ethanol. However, more… (More)

Stress and neuroactive steroids.

• Maria Luisa Barbaccia, Mariangela Serra, Robert H. Purdy, Giovanni Biggio
• International review of neurobiology
• 2001

The discovery that the endogenous steroid derivatives 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone, or 3 alpha,5 alpha-TH PROG) and 3 alpha,21-dihydroxy-5 alpha-pregnan-20-one… (More)

Vagus nerve stimulation increases norepinephrine concentration and the gene expression of BDNF and bFGF in the rat brain

• Paolo Follesa, Francesca Biggio, +6 authors Giovanni Biggio
• Brain Research
• 2007

Vagus nerve stimulation therapy, effective for treatment-resistant epilepsy, has recently been approved also for treatment-resistant depression; nevertheless, the molecular mechanism(s) underlying… (More)

Physiological modulation of GABA(A) receptor plasticity by progesterone metabolites.

• A Concas, Paolo Follesa, Maria Luisa Barbaccia, Robert H. Purdy, Giovanni Biggio
• European journal of pharmacology
• 1999

The possible functional relation between changes in brain and plasma concentrations of neurosteroids and the plasticity of gamma-aminobutyric acid type A (GABA(A)) receptors in the brain during… (More)

Stress and neurosteroids in adult and aged rats

• Maria Luisa Barbaccia, A Concas, Mariangela Serra, Giovanni Biggio
• Experimental Gerontology
• 1998

The progesterone derivative 3 alpha-hydroxy-5 alpha-pregnan-20 one (allopregnanolone/AP) and the deoxycorticosterone derivative 3 alpha-21-dihydroxy-5 alpha- pregnan-20 one… (More)

Decrease of homovanillic, dihydroxyphenylacetic acid and cyclic-adenosine-3',5'-monophosphate content in the rat caudate nucleus induced by the acute administration of an aminoacid mixture lacking…

• Giovanni Biggio, Maria Luisa Porceddu, Gian Luigi Gessa
• Journal of neurochemistry
• 1976

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