Giovanni Angelini

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Our labs are pursueing the goal of exactly defining the qualities of peptide antigenicity, immunogenicity and pathogenicity in order to develop safe specific immunotherapies by utilizing specific portions of disease-associated-proteins (DAPs). Using as a model the Pemphigus vulgaris antigen (PVA) desmoglein 3 (Dsg3), we have studied the murine humoral(More)
Language games represent one of the most fascinating challenges of research in artificial intelligence. In this paper we give an overview of WebCrow, a system that tackles crosswords using the Web as a knowledge base. This appears to be a novel approach with respect to the available literature. It is also the first solver for non-English crosswords and it(More)
ames and puzzles reproduce the complexity of the real world with " the smallest initial structures " (Minsky 1968), thus making their study important for both theoretical and practical issues. Since the birth of artificial intelligence (AI), games and puzzles have received much attention. The game that has captured most of the attention of computer(More)
Matrix metalloproteases (MMPs) are proteolytic enzymes involved in tissue remodelling and extracellular matrix (ECM) turnover. They are secreted in a latent form and activated at the cellular surface by a membrane type-1 MMP (MT1-MMP) and a tissue inhibitor of MMP-2 (TIMP-2) that is also responsible for striking a balance between the proteolytic enzymes and(More)
Term weighting systems are of crucial importance in Information Extraction and Information Retrieval applications. Common approaches to term weighting are based either on statistical or on natural language analysis. In this paper, we present a new algorithm that capitalizes from the advantages of both the strategies by adopting a machine learning approach.(More)
Term weighting is a crucial task in many Information Retrieval applications. Common approaches are based either on statistical or on natural language analysis. In this paper, we present a new algorithm that capitalizes from the advantages of both the strategies. In the proposed method, the weights are computed by a parametric function, called Context(More)
BACKGROUND Although described by Hippocrates in 400 B.C., pemphigus disease still needs a safe therapeutical approach, given that the currently used therapies (i.e. corticosteroids and immunosuppressive drugs) often provoke collateral effects. Here we present preliminary data on the possible use of a proteomics derived desmoglein peptide which appears(More)
INTRODUCTION Mycobacterium gordonae is one of the least pathogenic of the mycobacteria. This pathogen may produce caseating or non-caseating granulomas, and skin lesions showing acute or chronic inflammation with scattered histiocytes and giant cells have been seen. The mortality rate is less than 0.1%. Mycobacterium gordonae may be a marker of severe(More)