Giovanni Angelini

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Although described by Hippocrates in 400 B.C., pemphigus disease still needs a safe therapeutical approach, given that the currently used therapies (i.e. corticosteroids and immunosuppressive drugs) often provoke collateral effects. Here we present preliminary data on the possible use of a proteomics derived desmoglein peptide which appears promising in(More)
Our labs are pursueing the goal of exactly defining the qualities of peptide antigenicity, immunogenicity and pathogenicity in order to develop safe specific immunotherapies by utilizing specific portions of disease-associated-proteins (DAPs). Using as a model the Pemphigus vulgaris antigen (PVA) desmoglein 3 (Dsg3), we have studied the murine humoral(More)
Matrix metalloproteases (MMPs) are proteolytic enzymes involved in tissue remodelling and extracellular matrix (ECM) turnover. They are secreted in a latent form and activated at the cellular surface by a membrane type-1 MMP (MT1-MMP) and a tissue inhibitor of MMP-2 (TIMP-2) that is also responsible for striking a balance between the proteolytic enzymes and(More)
with “the smallest initial structures” (Minsky 1968), thus making their study important for both theoretical and practical issues. Since the birth of artificial intelligence (AI), games and puzzles have received much attention. The game that has captured most of the attention of computer scientists is chess. The founding fathers of AI such as McCarthy,(More)
We describe the case of a 52-year-old immunocompetent man with recurrent folliculitis on the left cheek, associated with intense pain. Bacteriological, mycological and Tzanck tests from the lesions were negative. Histopathological study showed an aspecific flogosis pattern. Virological tests carried out on swabs and paraffin-embedded tissue sections from(More)
INTRODUCTION Mycobacterium gordonae is one of the least pathogenic of the mycobacteria. This pathogen may produce caseating or non-caseating granulomas, and skin lesions showing acute or chronic inflammation with scattered histiocytes and giant cells have been seen. The mortality rate is less than 0.1%. Mycobacterium gordonae may be a marker of severe(More)
Term weighting systems are of crucial importance in Information Extraction and Information Retrieval applications. Common approaches to term weighting are based either on statistical or on natural language analysis. In this paper, we present a new algorithm that capitalizes from the advantages of both the strategies by adopting a machine learning approach.(More)
Term weighting is a crucial task in many Information Retrieval applications. Common approaches are based either on statistical or on natural language analysis. In this paper, we present a new algorithm that capitalizes from the advantages of both the strategies. In the proposed method, the weights are computed by a parametric function, called Context(More)