Giovanna Delogu

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Both anaesthetics and surgical trauma could strongly affect the production of tumour necrosis factor alpha (TNFalpha). During in vitro experiments the authors found that anaesthetics modulate the production of TNFalpha by peripheral blood mononuclear cells. Notably, Pentothal strongly increased the production of the cytokine as compared to both(More)
INTRODUCTION High mobility group box 1 (HMGB1) is a key mediator of inflammation that is actively secreted by macrophages and/or passively released from damaged cells. The proinflammatory role of HMGB1 has been demonstrated in both animal models and humans, since the severity of inflammatory response is strictly related to serum HMGB1 levels in patients(More)
The mechanisms initiating, regulating and sustaining the systemic stress response to a surgical injury have not all been identified yet. Recent studies point to the adipose tissue as a major endocrine system, the hormones of which influence energy homeostasis, glucose and lipid metabolism, vascular homeostasis, and immune response. Essential elements of(More)
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