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BACKGROUND A history of migraine has been proposed as a risk factor for cerebral ischaemia in women under 45. METHODS To investigate the association between history of migraine and cerebral ischaemia, we performed a case-control study of 308 patients aged 15-44, with either transient ischaemic attack (TIA) or stroke, and of 591 age- and sex-matched(More)
The pattern of DNA methylation established during embryonic development is necessary for the control of gene expression and is preserved during the replicative process. DNA regions of about 1-2 kb in size, termed CpG islands and located mostly in the promoter regions of housekeeping genes, are protected from methylation, despite being about 6-10 times(More)
1 T he metabolic syndrome, clinically defined by the Adult Treatment Panel III (ATPIII) (1), affects ϳ25% of western adults (2). The metabolic syndrome is closely linked to insulin resist a n c e a n d i m p l i e s a n i n c r e a s e d cardiovascular risk (3,4). Accumulating evidence suggests a link between body iron excess and insulin metabolism (5).(More)
In this study, the effect of polymorphisms in the leptin gene on the hematological variables in periparturient dairy cows was investigated. The hematological profile of 67 Holstein cows was assessed for 6 wk around calving. The DNA of the cows was genotyped at 6 polymorphic loci within the leptin gene, and 7 haplotypes were reconstructed. Significant(More)
We investigated some ultrastructural aspects of platelet activity in patients with classic migraine during an attack-free period. We focused on the production of malondialdehyde (MDA), the intracellular concentration of Ca++ and the membrane phospholipid structure using a DPH (1,6 diphenyl-1,3,5 hexatriene) fluorescent probe. Our study comprised 20 patients(More)
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