Giovanna Curti

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OBJECTIVE Despite enormous advancements in our comprehension of molecular mechanisms governing hematopoietic stem cells (HSCs) engraftment in the bone marrow, current clinical protocols of intravenous (IV) transplantation suffer from a relatively low seeding efficiency. To solve this problem, intrabone (IB) injection of HSCs has been proposed. However, the(More)
To evaluate a theoretical model for calculating free thyroid hormones, based on the law of mass action, we compared values for both calculated and measured free thyroxin and free triiodothyronine in a group of normal subjects. To determine whether the concentrations of circulating free hormones were also predictable from equilibrium considerations in(More)
BACKGROUND Pharmacokinetic modeling based on compartmentalization has provided a valuable tool to assess the clearance patterns of various glomerular and tubular agents. However, no models have been proposed thus far that combine vascular data and imaging data in order to gain a deeper knowledge on renal pathophysiology, and to obtain more diagnostic(More)
UNLABELLED Comparing the measurements of both glomerular filtration (GFR) and tubular excretion rates [TER(MAG3)] by multi-sample and single-sample methods has been performed after a single bolus injection of 3.7 MBq 51Cr-EDTA plus 37 MBq 99mTc-MAG3. METHODS We studied 17 healthy volunteers and 28 patients with a wide range of renal function. For each(More)
AIM Despite its enormous relevance, homing of hematopoietic stem cells (SCs) remains relatively uncertain due to the limitations of measuring small number of systemically administered cells in the different organs. Despite its high sensitivity, radionuclide detection has been relatively underutilized to this purpose since it cannot differentiate(More)
We have examined the in vivo production, distribution, metabolism, and excretion of radiolabeled triiodothyronine (T3) in eight normal humans using a new five-pool mammillary model which includes four extravascular pools to represent liver, kidney, skeletal muscle, and all other unquantified tissues. Trace amounts of [125I]T3 and [131I]T3 were injected and(More)