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An immunocytochemical study has been undertaken of cadherin expression in 11 benign melanocytic naevi and 14 malignant melanomas. Anti-pan-cadherin rabbit antibodies, which recognize multiple cadherin subtypes, demonstrated cadherin expression of moderate or strong intensity in 8 of 11 naevi. Expression was restricted to the more superficial melanocytes(More)
Characterisation and quantitation of epidermal growth factor receptors (EGFR) have been carried out on eight human squamous carcinoma cell lines and the results compared with those from simian virus transformed keratinocytes and normal keratinocytes grown under similar conditions. All cells tested possess both high and low affinity receptors with(More)
Using a polyclonal pan-cadherin antibody and a monoclonal E-cadherin antibody (HECD-1) we have investigated cadherin expression in lymphomas and reactive lymph nodes. Routinely processed tissue from nine reactive lymph nodes and 48 lymphomas (six T-cell, six high-grade B-cell, 15 low-grade B-cell, 13 anaplastic large cell and eight Hodgkin's disease) were(More)
E-cadherin is a morphoregulatory epithelial cell/cell adhesion molecule whose loss from carcinomas probably contributes to a more invasive tumour phenotype. Employing an immunohistochemical technique on 25 adenocarcinomas (8 from stomach, 10 breast, 7 colon) we compared E-cadherin expression and tumour morphology of carcinoma that had invaded vascular(More)
AIM To investigate the polarity of breast invasive ductal carcinoma cells by comparing the polarity of the tumour located within lymphovascular spaces with that located in the extravascular compartment. METHODS An immunohistochemical study identifying the apical HMFG-1, basolateral AUA-1, and basal laminin polarity markers of 11 cases of invasive ductal(More)
The ability of human keratinocytes and squamous carcinoma cell lines to attach lipid covalently to cell proteins has been examined using both palmitic and myristic acids. SDS-polyacrylamide gel analyses of the proteins labelled with these lipids demonstrated that each labelled a different set of proteins. Covalently protein bound palmitic acid could be(More)
OBJECTIVES To ascertain the extent of socioeconomic and health condition inequalities in people with diagnosed and undiagnosed diabetes and impaired glucose regulation (IGR) in random samples of the general population in England, as earlier diagnosis of diabetes and treatment of people with IGR can reduce adverse sequelae of diabetes. Various screening(More)
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