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Rett's syndrome is a genetic neurodevelopmental disorder with brainstem immaturity that aff ects one in 10 000 women. The condition shows the importance of the brainstem in cardiorespiratory medicine. There is a lack of understanding of the cardiorespiratory disturbance in the disorder within the medical community, which makes management a challenge.(More)
A preconditioned scheme for solving sparse symmetric eigenproblems is proposed. The solution strategy relies upon the DACG algorithm, which is a Preconditioned Conjugate Gradient algorithm for minimizing the Rayleigh Quotient. A comparison with the well established ARPACK code, shows that when a small number of the leftmost eigenpairs is to be computed,(More)
The Jacobi–Davidson (JD) algorithm was recently proposed for evaluating a number of the eigenvalues of a matrix. JD goes beyond pure Krylov-space techniques; it cleverly expands its search space, by solving the so-called correction equation, thus in principle providing a more powerful method. Preconditioning the Jacobi–Davidson correction equation is(More)
UNLABELLED Rett syndrome (RTT) is a severe neurodevelopmental disorder affecting almost exclusively females. The Hanefeld variant, or early-onset seizure variant, has been associated with mutations in CDKL5 gene. AIMS In recent years more than 60 patients with mutations in the CDKL5 gene have been described in the literature, but the cardiorespiratory(More)
We delineated the achievement of early speech-language milestones in 15 young children with Rett syndrome (MECP2 positive) in the first two years of life using retrospective video analysis. By contrast to the commonly accepted concept that these children are normal in the pre-regression period, we found markedly atypical development of speech-language(More)
Rett syndrome (RTT) is a developmental disorder characterized by regression of purposeful hand skills and spoken language, although some affected children retain some ability to speech. We assessed the communicative abilities of five young girls, who were later diagnosed with the preserved speech variant of RTT, during the pre-regression period (aged 12-24(More)
AIM Our aim was to contribute new findings related to the pre-regressional verbal development of females with a variant of Rett syndrome (RTT) as the loss of spoken language is one of the key clinical features of RTT, and it would be of particular interest to study the early speech-language development of females who are considered to have preserved some(More)
Recently an efficient method (DACG) for the partial solution of the symmetric generalized eigenproblem Ax = Bx has been developed, based on the conjugate gradient (CG) minimization of the Rayleigh quotient over successive deflated subspaces of decreasing size. The present paper provides a numerical analysis of the asymptotic convergence rate j of DACG in(More)
Rett syndrome (RTT) is a devastating neurodevelopmental disorder that affects one in ten thousand girls and has no cure. The majority of RTT patients display mutations in the gene that codes for the methyl-CpG-binding protein 2 (MeCP2). Clinical observations and neurobiological analysis of mouse models suggest that defects in the expression of MeCP2 protein(More)
Rett syndrome (RTT) is a neurodevelopmental disorder with one principal phenotype and several distinct, atypical variants (Zappella, early seizure onset and congenital variants). Mutations in MECP2 are found in most cases of classic RTT but at least two additional genes, CDKL5 and FOXG1, can underlie some (usually variant) cases. There is only limited(More)