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Phenotypic characterization of human colorectal cancer stem cells.

• Piero Dalerba, Scott J. Dylla, +11 authors Michael F. Clarke
• Proceedings of the National Academy of Sciences…
• 2007

Recent observations indicate that, in several types of human cancer, only a phenotypic subset of cancer cells within each tumor is capable of initiating tumor growth. This functional subset of cancer… (More)

Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine.

• Paola Filipazzi, Roberta Valenti, +7 authors Licia Rivoltini
• Journal of clinical oncology : official journal…
• 2007

PURPOSE Phenotypic and functional features of myeloid suppressor cells (MSC), which are known to serve as critical regulators of antitumor T-cell responses in tumor-bearing mice, are still poorly… (More)

Interleukin-12: biological properties and clinical application.

• Michele Del Vecchio, Emilio Bajetta, Stefania Canova, Michael T Lotze, Amy K. Wesa, Giorgio Parmiani
• Clinical cancer research : an official journal of…
• 2007

Interleukin-12 (IL-12) is a heterodimeric protein, first recovered from EBV-transformed B cell lines. It is a multifunctional cytokine, the properties of which bridge innate and adaptive immunity,… (More)

Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings.

• Filiberto Belli, Alessandro Testori, +26 authors Giorgio Parmiani
• Journal of clinical oncology : official journal…
• 2002

PURPOSE To determine the immunogenicity and antitumor activity of a vaccine consisting of autologous, tumor-derived heat shock protein gp96-peptide complexes (HSPPC-96, Oncophage; Antigenics, Inc,… (More)

Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma.

• Roberta Mortarini, Adriano Piris, +9 authors Giorgio Parmiani
• Cancer research
• 2003

Activation of CTL-mediated antitumor immunity to self-epitopes expressed by neoplastic cells is thought to be prevented, at any stage of tumor progression, by tolerance mechanisms. In contrast, in 74… (More)

Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1.

• Marcelle Marchand, Nicolas van Baren, +22 authors T. Boon
• International journal of cancer
• 1999

Thirty-nine tumor-bearing patients with metastatic melanoma were treated with 3 subcutaneous injections of the MAGE-3.A1 peptide at monthly intervals. No significant toxicity was observed. Of the 25… (More)

Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles

• Giovanna Andreola, Licia Rivoltini, +13 authors Stefano Fais
• The Journal of experimental medicine
• 2002

The hypothesis that FasL expression by tumor cells may impair the in vivo efficacy of antitumor immune responses, through a mechanism known as 'Fas tumor counterattack,' has been recently questioned,… (More)

A listing of human tumor antigens recognized by T cells: March 2004 update

• Luisa Novellino, Chiara Castelli, Giorgio Parmiani
• Cancer Immunology, Immunotherapy
• 2004

The technological advances occurred in the last few years have led to a great increase in the number of tumor associated antigens (TAA) that are currently available for clinical applications. In this… (More)

A listing of human tumor antigens recognized by T cells

• Nicolina Renkvist, Chiara Castelli, Paul F. Robbins, Giorgio Parmiani
• Cancer Immunology, Immunotherapy
• 2001

Identification of epitope mimics recognized by CTL reactive to the melanoma/melanocyte-derived peptide MART-1(27-35)

• Douglas J. Loftus, Chiara Castelli, +6 authors Licia Rivoltini
• The Journal of experimental medicine
• 1996

CTL reactivity to the epitope MART-1(27-35), of the melanoma (self) antigen MART-1/melan A is frequently observed in tumor-infiltrating lymphocytes and may be readily elicited from the peripheral… (More)

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