3,4-Methylenedioxymethamphetamine (MDMA)-induced neurotoxicity leads to the formation of quinone metabolities and hydroxyl radicals and then to the production of reactive oxygen species (ROS). We evaluated the effect of a single dose of MDMA (20 mg/kg, i.p.) on the enzymatic and nonenzymatic cellular antioxidant defense system in different areas of rat… (More)
BACKGROUND To investigate the cardiotoxic role of reactive oxygen species (ROS) and of products derived from catecholamines auto-oxidation, we studied: (1) the response of antioxidant cardiac cellular defence systems to oxidative stress induced by norepinephrine (NE) administration, (2) the effect of NE administration on cardiac beta1-adrenergic receptors… (More)
Male rats were treated with cocaine by utilizing two different experimental paradigms. One group of animals received a low dose (10 mg/kg, IP) of cocaine for 7 days. A second group received 40 mg/kg IP of cocaine for 3 days. In both experimental groups, half the animals were concomitantly treated with 0.25 mg/kg IP… (More)
Valeriana adscendens Trel. (Valerianaceae) is a psychoactive plant usually used in magical-therapeutic rituals in traditional practices of the Northern Peruvian Andes. Previous studies have been carried out on extracts of aerial parts in order to validate its traditional use. The results indicated that Valeriana adscendens exerts important effects on the… (More)
In this report a short and efficient synthesis of the dibenz[b,f]oxepin framework through intramolecular SNAr and McMurry reactions is described. The diaryl ethers required for the McMurry reaction have been obtained in good yields under microwave-assisted conditions of the reaction of salicylaldehydes with fluorobenzaldehydes without catalysts. Application… (More)
Dexamethasone (DEX) is a highly potent logacting glucocorticoid with negligible sodium retaining properties. Recent evidence has been obtained for an interference caused by DEX on morphine induced analgesia, hypermotility, constipation and contraction of guinea pig isolated ileum. Studies in our laboratory have recently focused on the relationship between… (More)
Given a nonlinear vector-valued programming problem involving generalized pseu-dolinear functions (i.e. η-pseudolinear functions) it is shown that every efficient solution is properly efficient under some boundedness condition.
We consider three applications of invexity and generalized invexity to a multiob-jective (Pareto) optimization problem: i) It is shown that in a Pareto optimization problem involving generalized pseudolinear functions, every efficient solution is a properly efficient solution under some boundedness condition. ii) Some remarks are made on semilocally… (More)