Giorgio E. M. Melloni

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MOTIVATION Cellular mRNA levels originate from the combined action of multiple regulatory processes, which can be recapitulated by the rates of pre-mRNA synthesis, pre-mRNA processing and mRNA degradation. Recent experimental and computational advances set the basis to study these intertwined levels of regulation. Nevertheless, software for the(More)
A key challenge in the analysis of cancer genomes is the identification of driver genes from the vast number of mutations present in a cohort of patients. DOTS-Finder is a new tool that allows the detection of driver genes through the sequential application of functional and frequentist approaches, and is specifically tailored to the analysis of few tumor(More)
Since the publication of this article, the authors have identified an error within Table 2, namely that the AML subgroups listed at the bottom of the table were incorrect. The correct table is shown here. The article has also been rectified, and now carries the correct information. The Publishers apologize for any inconvenience this has caused. a TCGA b(More)
The increasing availability of resequencing data has led to a better understanding of the most important genes in cancer development. Nevertheless, the mutational landscape of many tumor types is heterogeneous and encompasses a long tail of potential driver genes that are systematically excluded by currently available methods due to the low frequency of(More)
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