Giorgio Bianciardi

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The skeleton is an important representation for shape analysis. A common approach for generating discrete skeletons takes three steps: 1) computing the distance map, 2) detecting maximal disks from the distance map, and 3) linking the centers of maximal disks (CMDs) into a connected skeleton. Algorithms using approximate distance metrics are abundant and(More)
PURPOSE To determine annual rates of volumetric changes in the whole-brain parenchyma of patients with relapsing-remitting and secondary progressive multiple sclerosis (MS) and test the hypothesis that these changes correlate with clinical disability. MATERIALS AND METHODS A computer-assisted segmentation technique with thin-section magnetic resonance(More)
We present a robust and efficient algorithm for calculating the centerline of a computer-generated colon model created from helical CT image data. The centerline is an essential aid for navigating through complex anatomy such as the colon. Our algorithm involves three steps. In the first step, we generate a 3D skeleton of the binary colon volume using a(More)
Image intensity standardization is a recently developed postprocessing method that is capable of correcting the signal intensity variations in MR images. We evaluated signal intensity of healthy and diseased tissues in 10 multiple sclerosis (MS) patients based on standardized dual fast spin-echo MR images using a numerical postprocessing technique. The main(More)
The determination of the composition of the microbial community in the oral cavity is usually based on cultivation methods; however, nearly half of the bacteria in the saliva and the dental plaque are not cultivable. In this study, we evaluated the difference in oral microbial diversity between children with severe early-childhood caries (S-ECC) and(More)
OBJECTIVE The distinct trajectories of patients with autism spectrum disorders (ASDs) have not been extensively studied, particularly regarding clinical manifestations beyond the neurobehavioral criteria from the Diagnostic and Statistical Manual of Mental Disorders. The objective of this study was to investigate the patterns of co-occurrence of medical(More)
PURPOSE To determine the fractional brain tissue volume changes in the gray matter and white matter of patients with relapsing-remitting multiple sclerosis (MS) and to correlate these measurements with clinical disability and total lesion load. MATERIALS AND METHODS Thirty patients with relapsing-remitting MS and 25 healthy control subjects underwent(More)
BACKGROUND AND PURPOSE Evaluation of the spinal cord is important in the diagnosis and follow-up of patients with multiple sclerosis. Our purpose was to investigate diffusion tensor imaging (DTI) changes in different regions of normal-appearing spinal cord (NASC) in relapsing-remitting multiple sclerosis (RRMS). METHODS Axial DTI of the cervical spinal(More)
Virtual colonoscopy is a minimally invasive technique that enables early detection of colorectal polyps and cancer. Normally, a patient's bowel is prepared with colonic lavage and gas insufflation prior to computed tomography scanning. An important step for 3D analysis of the image volume is segmentation of the colon. The high-contrast gas/tissue interface(More)
One key cell-signaling event central to inflammation in kidney diseases, including chronic renal allograft dysfunction or disease (CRAD), is the activation of NF-kappaB, which controls transcription of numerous proinflammatory mediators. Glycogen synthase kinase (GSK) 3beta is an indispensable element of NF-kappaB activation, however, the exact role of(More)