Giorgi Papashvili

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Established that one of the factors promoting development of the psycho-nervous diseases, are various kinds of social deprivation. The purpose of this study was investigation of importance of social interactions at the early period of postnatal in development of resistance of the nervous system against the psychogenic stress in the adult rats. At weaning,(More)
In humans, deletions/mutations in the CHL1/CALL gene are associated with mental retardation and schizophrenia. Juvenile CHL1-deficient (CHL1(-/-) ) mice have been shown to display abnormally high numbers of parvalbumin-expressing (PV(+) ) hippocampal interneurons and, as adults, display behavioral traits observed in neuropsychiatric disorders. Here, we(More)
Mice deficient in the extracellular matrix glycoprotein tenascin-C (TNC-/-) express a deficit in specific forms of hippocampal synaptic plasticity, which involve the L-type voltage-gated Ca2+ channels (L-VGCCs). The mechanisms underlying this deficit and its functional implications for learning and memory have not been investigated. In line with previous(More)
This paper gives the results on the studies of the effect of multiple generalized seizures (MGSs) on the wakefulness-sleep cycle (WSC). The adult Wister rats served as the experimental objects. The animals, under chloral hydrate anesthesia (35-40mg/kg) were stereotaxically implanted with stainless metal electrodes aimed into the neocortex and dorsal(More)
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