Gino V. Limmon

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Regeneration of alveolar epithelia following severe pulmonary damage is critical for lung function. We and others have previously shown that Scgb1a1-expressing cells, most likely Clara cells, can give rise to newly generated alveolar type 2 cells (AT2s) in response to severe lung damage induced by either influenza virus infection or bleomycin treatment. In(More)
The lung comprises an extensive surface of epithelia constantly exposed to environmental insults. Maintaining the integrity of the alveolar epithelia is critical for lung function and gaseous exchange. However, following severe pulmonary damage, what progenitor cells give rise to alveolar type I and II cells during the regeneration of alveolar epithelia has(More)
With the incessant challenge of exposure to the air we breathe, lung tissue suffers the highest levels of oxygen tension and thus requires robust antioxidant defenses. Furthermore, following injury or infection, lung tissue faces the additional challenge of inflammation-induced reactive oxygen and nitrogen species (ROS/RNS). Little is known about the(More)
BACKGROUND Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to influenza virus infection, however, how aging affects the lung tissue damage and repair has not been completely elucidated. METHODS Aged(More)
BACKGROUND Management of influenza, a major contributor to the worldwide disease burden, is complicated by lack of reliable methods for early identification of susceptible individuals. Identification of molecular markers that can augment existing diagnostic tools for prediction of severity can be expected to greatly improve disease management capabilities.(More)
Citation Yin, Lu, et al. "Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia." The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Background: Influenza virus infection causes significantly higher levels of morbidity and mortality in(More)
  • Citation Zheng, Gino V Dahai, Lu Limmon, Nicola H N Yin, Hanry Leung, Vincent T K Yu +12 others
  • 2013
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Regeneration of alveolar epithelia following severe pulmonary damage is critical for lung function. We and others have previously shown that Scgb1a1-expressing cells, most likely Clara cells, can give rise to newly generated(More)
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