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An iterative algorithm is presented for accelerated reconstruction of cone beam transmission CT data (CBCT). CBCT supplies an attenuation map for SPECT attenuation compensation and anatomical correlation. Iterative algorithms are necessary to reduce truncation artifacts and 3D reconstruction artifacts. An existing transmission maximum-likelihood algorithm(More)
Lignocaine (lidocaine) and beta-adrenoceptor antagonists are widely used after acute myocardial infarction. The therapeutic value of these agents depends on the achievement and maintenance of safe and effective plasma concentrations. Lignocaine pharmacokinetics after acute myocardial infarction (MI) are controlled by a number of variables. The single most(More)
Nasal airflow patterns were studied by using xenon 133 gas to image the course taken by air as it flowed through a plastic model of the human nasal cavity. The model was produced from the head of a human cadaver, and was anatomically correct. A needle catheter was used to infuse the radioactive xenon into a continuous flow of room air maintained through the(More)
For the purpose of radiation dose estimates, organ assays and excretion measurements of the Tc-99m and In-111 complexes with DTPA were conducted in dogs at various time intervals up to 24 hr, and the results compared with available human data. The peak concentration of the Tc-99m complex, at 3 min after injection, was 5% of the administered dose for one(More)
Mixed leukocyte suspensions obtained after gravity sedimentation of red cells and labeled with 111In lipophilic chelates are now widely used clinically for abscess localization at many medical centers. So far, labeling with 111In-oxine or tropolone has been more successful than any 99mTc method. More sophisticated approaches are available for isolation and(More)
The attenuation of photons by the breasts and other soft tissue overlying the chest may decrease the diagnostic accuracy of SPECT myocardial imaging. In this experiment, we measured the attenuation distortion of myocardial polar maps using a thorax phantom with a cardiac insert and added breast tissue. The distortion was measured using a regional(More)
UNLABELLED We set out to determine the oxygen concentration of the argon-oxygen mixture in the technegas generator where technegas-like behavior changes to pertechnegas-like behavior which allows [99mTc]pertechnetate to enter the solution. METHODS We prepared radioaerosols analogous to technegas and pertechnegas, with oxygen concentrations between 0% and(More)
Radioimmunoimaging of experimentally-induced canine thrombi has previously been achieved with iodine-131- and indium-111-labeled (131I and 111In) anti-fibrin T2G1s monoclonal antibody (MAb). We now compare T2G1s to another anti-fibrin MAb, designated GC4, for imaging fresh and aged canine thrombi. GC4 is specific for a neoepitope exposed on fibrin later in(More)
In view of the current interest in the use of lymphoid cells in adoptive immunotherapy of patients with advanced cancer, we have studied the homing patterns of various lymphoid effector cells in mammary-tumor-bearing mice. Single-cell suspensions of total splenocytes, natural killer (NK) cells, and lymphokine-activated killer (LAK) cells were prepared from(More)
A variety of radioactive agents, injected directly intravenously have demonstrated foci of inflammation by gamma camera imaging, avoiding the in vitro preparation of labeled leukocytes. This study sought to find out if any of these agents mimicked the biodistribution in abscesses and non-target organs of labeled mixed leukocyte suspensions. Eight different(More)