• Publications
  • Influence
4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent
TLDR
It is concluded that at low concentrations, glucoraphasatin, either intact and/or through the formation of 4-methylsulfanyl-3-butenyl isothiocyanate, is a potent inducer of hepatic enzymes involved in the detoxification of chemical carcinogens and merits further investigation for chemopreventive activity. Expand
A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase
TLDR
Considering the ability of Daikon glucosinolates to effectively enhance detoxification enzymes, in particular glutathione S-transferase, it may be inferred that consumption of this vegetable may possess significant chemopreventive activity and warrants further evaluation through epidemiology and studies in animal models of cancer. Expand
Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality
TLDR
The ability of isothiocyanates to enhance hepatic microsomal epoxide hydrolase and glucuronosyl transferase activities is dependent on the nature of the side chain, and in the case of sulforaphane, the naturally occurring R-enantiomer increased both activities, whereas, in contrast, activities were impaired in the cases of the S- enantiomer. Expand
Long-chain Glucosinolates from Arabis turrita: Enzymatic and Non-enzymatic Degradations
TLDR
GC-MS analysis showed the presence of long-chain olefinic isothiocyanates (ITCs) along with other the long- chain thiofunctionalized GL breakdown products. Expand
Erratum to: A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase
TLDR
Considering the ability of Daikon glucosinolates to effectively enhance detoxification enzymes, in particular glutathione S-transferase, it may be inferred that consumption of this vegetable may possess significant chemopreventive activity and warrants further evaluation through epidemiology and studies in animal models of cancer. Expand
Isothiocyanates as acetylcholinesterase inhibitors and their sources from croatian wild-growing plants
TLDR
Inhibition of acetylcholinesterase (AChE) serves as a strategy for the treatment of AD (as well as some other neurological diseases), and various natural products, such as alkaloids, flavonoids, terpenes, etc. have long been recognized as such inhibitors. Expand
GLUCOSINOLATES IN THE ENDEMIC PLANTS OF THE TRIBE ALYSSEAE (BRASSICACEAE) WILD-GROWING IN CROATIA
TLDR
The aim of this study was to characterize and quantify GLs in different plant parts according to the ISO 9167-1 official method based on the HPLC analysis of desulfo-GLs and by GC/MS analysis of the volatile fractions obtained after enzyme hydrolysis. Expand
Glucosinolate Profile of Croatian Stenoendemic Plant Fibigia triquetra (DC.) Boiss. ex Prantl.
TLDR
Differences in chemotaxonomy are shown between F. triquetra and the related Degenia velebitica (Degen) Hayek as well as other investigated species of the genus Fibigia. Expand