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GABA(A) receptor pi (GABRP) stimulates basal-like breast cancer cell migration through activation of extracellular-regulated kinase 1/2 (ERK1/2).

• Gina M. Sizemore, Steven T Sizemore, Darcie D. Seachrist, Ruth A. Keri
• The Journal of biological chemistry
• 2014

Breast cancer is a heterogeneous disease comprised of distinct subtypes predictive of patient outcome. Tumors of the basal-like subtype have a poor prognosis due to inherent aggressiveness and the… (More)

The ETS family of oncogenic transcription factors in solid tumours

• Gina M. Sizemore, Jason R. Pitarresi, Subhasree Balakrishnan, Michael C. Ostrowski
• Nature Reviews Cancer
• 2017

Findings over the past decade have identified aberrant activation of the ETS transcription factor family throughout all stages of tumorigenesis. Specifically in solid tumours, gene rearrangement and… (More)

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.

• Xin Liu, Jason R. Pitarresi, +21 authors Michael C. Ostrowski
• Genes & development
• 2016

The contribution of the microenvironment to pancreatic acinar-to-ductal metaplasia (ADM), a preneoplastic transition in oncogenic Kras-driven pancreatic cancer progression, is currently unclear. Here… (More)

FOXC1 is enriched in the mammary luminal progenitor population, but is not necessary for mouse mammary ductal morphogenesis.

• Gina M. Sizemore, Steven T Sizemore, +5 authors Ruth A. Keri
• Biology of reproduction
• 2013

Expression of FOXC1, a forkhead box transcription factor, correlates with the human basal-like breast cancer (BLBC) subtype, and functional analyses have revealed its importance for in vitro… (More)

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

• Anisha M. Hammer, Gina M. Sizemore, +13 authors Michael C. Ostrowski
• Neoplasia
• 2017

The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse… (More)

Hypomethylation of the MMP7 promoter and increased expression of MMP7 distinguishes the basal-like breast cancer subtype from other triple-negative tumors

• Steven T Sizemore, Gina M. Sizemore, +6 authors Ruth A. Keri
• Breast Cancer Research and Treatment
• 2014

Identification of novel targets for the treatment of basal-like breast cancer is essential for improved outcomes in patients with this disease. This study investigates the association of MMP7… (More)

Temporal Lobe Epilepsy, Stroke, and Traumatic Brain Injury: Mechanisms of Hyperpolarized, Depolarized, and Flow-Through Ion Channels Utilized as Tri-Coordinate Biomarkers of Electrophysiologic…

• Gina M. Sizemore, Brandon P Lucke-Wold, Charles Lee Rosen, James William Simpkins, Sanjay Bhatia, Dandan Sun
• OBM neurobiology
• 2018

The brain is an integrated network of multiple variables that when compromised create a diseased state. The neuropathology of temporal lobe epilepsy (TLE), stroke, and traumatic brain injury (TBI)… (More)

Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.

• Steven T Sizemore, Rahman Mohammad, +5 authors Fen Xia
• Molecular cancer research : MCR
• 2018

PARP inhibitors (PARPi) are potentially effective therapeutic agents capable of inducing synthetic lethality in tumors with deficiencies in homologous recombination (HR)-mediated DNA repair such as… (More)

Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair

• Steven T Sizemore, Shizu Yabe, +10 authors Fen Xia
• Cell Research
• 2018

Resistance to genotoxic therapies is a primary cause of treatment failure and tumor recurrence. The underlying mechanisms that activate the DNA damage response (DDR) and allow cancer cells to escape… (More)

Protein Kinase C Beta in the Tumor Microenvironment Promotes Mammary Tumorigenesis

• Julie A. Wallace, Jason R. Pitarresi, +9 authors Michael C. Ostrowski
• Front. Oncol.
• 2014

Protein kinase C beta (PKCβ) expression in breast cancer is associated with a more aggressive tumor phenotype, yet the mechanism for how PKCβ is pro-tumorigenic in this disease is still unclear.… (More)

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