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Patients with diabetic neuropathy often have neuropathic pain. The purpose of our work was to investigate the effects of high-intensity focused ultrasound (HIFU) on the conduction block of normal and neuropathic nerves for soothing pain. Adult male Sprague-Dawley rats were used, and diabetes was induced by streptozotocin injection. Diabetic neuropathy was(More)
A novel active surface Laplacian electroencephalogram (LEEG) sensor for the real-time mu rhythms detection has been developed in our study. Analog LEEG signals with high signal to noise ratio obtained directly by using the active sensor can reduce the duration and quantum error of digital signal processing and computation for the quick and precise control(More)
Focused ultrasound (FUS) combined with microbubbles has been shown to be a noninvasive and targeted drug delivery technique for brain tumor treatment. The purpose of this study was to measure the kinetics of Gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) in glioma-bearing rats in the presence of FUS-induced blood-brain barrier disruption (BBB-D)(More)
Measurements of ultrasonic attenuation in the sciatic nerves of rats were performed to verify the feasibility of ultrasound diagnosis of peripheral neuropathy and to avoid damage to the nerves caused by overheating in pain management applications. A rat model of diabetic peripheral neuropathy was established. The proximal-segment and middle-segment sciatic(More)
Many studies have investigated how to use focused ultrasound (FUS) to temporarily disrupt the blood-brain barrier (BBB) in order to facilitate the delivery of medication into lesion sites in the brain. In this study, through the setup of a real-time system, FUS irradiation and injections of ultrasound contrast agent (UCA) and Gadodiamide (Gd, an MRI(More)
Piezocomposites with 1-3 connectivity have been extensively used in medical imaging transducers and high-intensity focused ultrasound transducers, but most studies of 1-3 piezocomposites address medical imaging applications. The purpose of this study was to completely investigate 1-3 composites specifically for high-power ultrasonic transducer applications(More)
Considering the damage to normal tissues during the high-intensity focused ultrasound ablation of the tumor is important. The purpose of this work was to design the annular array under the considerations of preventing the skin burn and damage to normal tissues behind the tumor target. Based on the Rayleigh–Summerfield pressure integral, the numerical(More)
The temporal course of diabetic polyneuropathy in a rat model plays a critical role in studies on diabetic polyneuropathy treatment. In this study, the temporal course of neuropathic symptoms was investigated in diabetic rats induced by streptozotocin and evaluated by nerve conduction velocity and behavioral assays, including the von Frey test for(More)
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