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PURPOSE Vessel deformations have been implicated in endoluminal device fractures, and therefore better understanding of these deformations could be valuable for device regulation, evaluation, and design. The purpose of this study is to describe geometric changes of the superficial femoral artery (SFA) resulting from hip and knee flexion in older subjects.(More)
OBJECTIVE To assess the distribution of pressure and shear-related forces acting on atherosclerotic plaques and their association with lesion characteristics using coronary CT angiography (cCTA)-based computational fluid dynamics (CFD) model of epicardial coronary arteries. METHODS Patient-specific models of epicardial coronary arteries were reconstructed(More)
OBJECTIVE We developed a novel method using anatomic markers along the thoracic aorta to accurately quantify longitudinal and circumferential cyclic strain in nondiseased thoracic aortas during the cardiac cycle and to compute age-related changes of the human thoracic aorta. METHODS Changes in thoracic aorta cyclic strains were quantified using(More)
The knowledge of dynamic changes in the vascular system has become increasingly important in ensuring the safety and efficacy of endovascular devices. We developed new methods for quantifying in vivo three-dimensional (3D) arterial deformation due to pulsatile and nonpulsatile forces. A two-dimensional threshold segmentation technique combined with a level(More)
PURPOSE To quantify in vivo deformations of the abdominal aorta and common iliac arteries (CIAs) caused by musculoskeletal motion. METHODS Seven healthy subjects (age 34+/-11 years, range 24-50) were imaged in the supine and fetal positions (hip flexion angle 134.0 degrees +/-9.7 degrees ) using contrast-enhanced magnetic resonance angiography.(More)
PURPOSE To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo. MATERIALS AND METHODS C57BL/6J and apoE(-/-) mice underwent three-dimensional (3D) time-of-flight MR angiography to position cardiac-gated 2D slices at four locations along the abdominal aorta where circumferential cyclic strain and lumen(More)
Accurate quantification of changes in length, curvature, and bifurcation angles of coronary arteries due to cardiac motion is important for the design of coronary stents. A new method is developed to describe the dynamic characteristics of the human coronary artery. From cardiac-gated computed tomography (CT) data, 3-D surface geometry and centerline paths(More)
Computational fluid dynamic methods are currently being used clinically to simulate blood flow and pressure and predict the functional significance of atherosclerotic lesions in patient-specific models of the coronary arteries extracted from noninvasive coronary computed tomography angiography (cCTA) data. One such technology, FFRCT, or noninvasive(More)
Image-based blood flow computation provides great promise for evaluation of vascular devices and assessment of surgical procedures. However, many previous studies employ idealized arterial and device models or only patient-specific models from the image data after device deployment, since the tools for model construction are unavailable or limited and(More)
PURPOSE To quantify respiration-induced deformations of the superior mesenteric artery (SMA), left renal artery (LRA), and right renal artery (RRA) in patients with small abdominal aortic aneurysms (AAAs). MATERIALS AND METHODS Sixteen men with AAAs (age 73 y ± 7) were imaged with contrast-enhanced magnetic resonance angiography during inspiratory and(More)