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The knowledge of dynamic changes in the vascular system has become increasingly important in ensuring the safety and efficacy of endovascular devices. We developed new methods for quantifying in vivo three-dimensional (3D) arterial deformation due to pulsatile and nonpulsatile forces. A two-dimensional threshold segmentation technique combined with a level(More)
OBJECTIVE To assess the distribution of pressure and shear-related forces acting on atherosclerotic plaques and their association with lesion characteristics using coronary CT angiography (cCTA)-based computational fluid dynamics (CFD) model of epicardial coronary arteries. METHODS Patient-specific models of epicardial coronary arteries were reconstructed(More)
PURPOSE Vessel deformations have been implicated in endoluminal device fractures, and therefore better understanding of these deformations could be valuable for device regulation, evaluation, and design. The purpose of this study is to describe geometric changes of the superficial femoral artery (SFA) resulting from hip and knee flexion in older subjects.(More)
OBJECTIVE We developed a novel method using anatomic markers along the thoracic aorta to accurately quantify longitudinal and circumferential cyclic strain in nondiseased thoracic aortas during the cardiac cycle and to compute age-related changes of the human thoracic aorta. METHODS Changes in thoracic aorta cyclic strains were quantified using(More)
Accurate quantification of changes in length, curvature, and bifurcation angles of coronary arteries due to cardiac motion is important for the design of coronary stents. A new method is developed to describe the dynamic characteristics of the human coronary artery. From cardiac-gated computed tomography (CT) data, 3-D surface geometry and centerline paths(More)
PURPOSE To develop methods to quantify cyclic strain, motion, and curvature of the murine abdominal aorta in vivo. MATERIALS AND METHODS C57BL/6J and apoE(-/-) mice underwent three-dimensional (3D) time-of-flight MR angiography to position cardiac-gated 2D slices at four locations along the abdominal aorta where circumferential cyclic strain and lumen(More)
PURPOSE To quantify in vivo deformations of the abdominal aorta and common iliac arteries (CIAs) caused by musculoskeletal motion. METHODS Seven healthy subjects (age 34+/-11 years, range 24-50) were imaged in the supine and fetal positions (hip flexion angle 134.0 degrees +/-9.7 degrees ) using contrast-enhanced magnetic resonance angiography.(More)
Endovascular stents are the mainstay of interventional cardiovascular medicine. Technological advances have reduced biological and clinical complications but not mechanical failure. Stent strut fracture is increasingly recognized as of paramount clinical importance. Though consensus reigns that fractures can result from material fatigue, how fracture is(More)
Computational fluid dynamic methods are currently being used clinically to simulate blood flow and pressure and predict the functional significance of atherosclerotic lesions in patient-specific models of the coronary arteries extracted from noninvasive coronary computed tomography angiography (cCTA) data. One such technology, FFRCT, or noninvasive(More)
OBJECTIVES The purpose of this study was to characterize the hemodynamic force acting on plaque and to investigate its relationship with lesion geometry. BACKGROUND Coronary plaque rupture occurs when plaque stress exceeds plaque strength. METHODS Computational fluid dynamics was applied to 114 lesions (81 patients) from coronary computed tomography(More)