Gillian C. Bell

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BACKGROUND Active clinical decision support (CDS) delivered through an electronic health record (EHR) facilitates gene-based drug prescribing and other applications of genomics to patient care. OBJECTIVE We describe the development, implementation, and evaluation of active CDS for multiple pharmacogenetic test results reported preemptively. MATERIALS(More)
This article provides nomenclature recommendations developed by an international workgroup to increase transparency and standardization of pharmacogenetic (PGx) result reporting. Presently, sequence variants identified by PGx tests are described using different nomenclature systems. In addition, PGx analysis may detect different sets of variants for each(More)
PURPOSE The development and implementation of a multidisciplinary pharmacogenomics clinic within the framework of an established community-based medical genetics program are described. SUMMARY Pharmacogenomics is an important component of precision medicine that holds considerable promise for pharmacotherapy optimization. As part of the development of a(More)
BACKGROUND Despite growing emphasis on preventive services, physicians still provide low levels of these services to their patients. Barriers to providing preventive services might be modified by more effective teaching models at the residency level. The purpose of this study was to evaluate a practice-based teaching model designed to increase resident(More)
BACKGROUND The increasing practicality of genomic sequencing technology has led to its incorporation into routine clinical practice. Successful identification and targeting of driver genomic alterations that provide proliferative and survival advantages to tumor cells have led to approval and ongoing development of several targeted cancer therapies. Within(More)
Genotype and Use of Ondansetron and Tropisetron Gillian C. Bell, Kelly E. Caudle, Michelle Whirl-Carrillo, Ronald J. Gordon, Keiko Hikino, Cynthia A. Prows, Andrea Gaedigk, Jose A.G. Agundez, Senthilkumar Sadhasivam, Teri E. Klein, Matthias Schwab 12, 13 Personalized Medicine Program, Mission Health, Asheville, NC, USA Department of Pharmaceutical Sciences,(More)
OBJECTIVES To evaluate faculty members' and students' perceptions of study strategies and materials. METHODS Focus groups were conducted with course directors and first- and second-year students to generate ideas relating to use of course materials, technology, class attendance, and study strategies for mastering class concepts. RESULTS Students and(More)
In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additional treatment options.