Gilles Francony

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OBJECTIVE To compare the effects of equimolar doses of 20% mannitol solution and of 7.45% hypertonic saline solution (HSS) in the treatment of patients with sustained elevated intracranial pressure (ICP). DESIGN Parallel, randomized, controlled trial. SETTING Two intensive care units in a university hospital. PATIENTS A total of 20 stable patients(More)
BACKGROUND The accuracy of combined clinical examination (CE) and chest radiography (CXR) (CE + CXR) vs thoracic ultrasonography in the acute assessment of pneumothorax, hemothorax, and lung contusion in chest trauma patients is unknown. METHODS We conducted a prospective, observational cohort study involving 119 adult patients admitted to the ED with(More)
Preventive treatments of traumatic intracranial hypertension are not yet established. We aimed to compare the efficiency of half-molar sodium lactate (SL) versus saline serum solutions in preventing episodes of raised intracranial pressure (ICP) in patients with severe traumatic brain injury (TBI). This was a double-blind, randomized controlled trial(More)
The early diagnosis of traumatic internal carotid artery dissection (TICAD) is essential for initiating appropriate treatment and improving outcome. We searched for criteria from transcranial Doppler (TCD) measurements on admission that could be associated with subsequent TICAD diagnosis in patients with traumatic brain injury (TBI). We conducted a(More)
Y. van de Looij, H. Lahrech, G. Francony, O. Carle, R. Farion, C. Segebarth, J-F. Payen INSERM U594, Grenoble, France, Univ Joseph Fourier, Grenoble, France Introduction Posttraumatic cerebral edema represents the leading cause of death and neurological sequels. However, early characterization of this edema is poorly documented, although it could affect the(More)
BACKGROUND After elective craniotomy for brain surgery, patients are usually admitted to an intensive care unit (ICU). We sought to identify predictors of postoperative complications to define perioperative conditions that would safely allow ICU bypass. METHODS This observational cohort study enrolled 358 patients admitted to neuro-ICU after elective(More)
Erythropoietin (Epo) is gaining interest in various neurological insults as a possible neuroprotective agent. We determined the effects of recombinant human Epo (rhEpo, 5000 IU per kg bw) on brain edema induced in rats by traumatic brain injury (TBI; impact-acceleration model; rhEpo administration 30 mins after injury). Magnetic resonance imaging (MRI) and(More)
BACKGROUND Detecting patients at risk for secondary neurological deterioration (SND) after mild to moderate traumatic brain injury is challenging. OBJECTIVE To assess the diagnostic accuracy of transcranial Doppler (TCD) on admission in screening these patients. METHODS This prospective, observational cohort study enrolled 98 traumatic brain injury(More)
Cerebral edema is one of the main acute complications arising after irradiation of brain tumors. Microbeam radiation therapy (MRT), an innovative experimental radiotherapy technique using spatially fractionated synchrotron x-rays, has been shown to spare radiosensitive tissues such as mammal brains. The aim of this study was to determine if cerebral edema(More)
OBJECTIVE To investigate the effects of carbamylated erythropoietin, a modified erythropoietin lacking erythropoietic activity, on brain edema and functional recovery in a model of diffuse traumatic brain injury. DESIGN Adult male Wistar rats. SETTING Neurosciences and physiology laboratories. INTERVENTIONS Thirty minutes after diffuse traumatic brain(More)