Giles O. Hellawell

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The type 1 insulin-like growth factor receptor (IGF1R) mediates tumor cell growth, adhesion, and protection from apoptosis. High plasma IGF-I levels predispose to prostate cancer, but there is no consensus regarding IGF1R expression in primary and metastatic prostate cancer. Recent studies in a human cell line and a mouse model suggest that metastatic(More)
Purpose: To evaluate the accuracy and biological basis for [ 11 C]choline-PET-CT in the nodal staging of high risk localized prostate cancer patients. Experimental Design: Twenty-eight patients underwent dynamic [ 11 C]choline-PET-CT of the pelvis and lower abdomen prior to extended laparoscopic pelvic lymph node dissection (eLPL). The sensitivity and(More)
BACKGROUND Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wide association studies implicate RAD51B(More)
Running Title: [ 11 C]Choline PET-CT for nodal evaluation in prostate cancer Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. [ 11 C]Choline PET-CT for nodal evaluation in prostate cancer Statement of Translational relevence This study establishes the feasibility of using [ 11 C]choline-PET CT as a(More)
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