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SUMMARY DNA methylation is a major epigenetic modification in human cells. Illumina HumanMethylation27 BeadChip makes it possible to quantify the methylation state of 27 578 loci spanning 14 495 genes. We developed a non-parametric normalization method to correct the spatial background noise in order to improve the signal-to-noise ratio. The prediction(More)
Copulas are a useful tool to model multivariate distributions. While there exist various families of bivariate copulas, much less work has been done when the dimension is higher. We propose a class of multivariate copulas based on products of transformed bivariate copulas. The analytical forms of the copulas within this class allow to naturally associate a(More)
HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la(More)
In this paper, we address the issue of estimating the parameters of general multivariate copulas, that is, copulas whose partial derivatives may not exist. To this aim, we consider a weighted least-squares estimator based on dependence coefficients, and establish its consistency and asymptotic normality. The estimator’s performance on finite samples is(More)
Copulas are increasingly studied both in theory and practice as they are a convenient tool to construct multivariate distribution functions. However the material essentially covers the bi-variate case while in applications the number of variables is much higher. Furthermore, when one wants to take into account tail dependence, a desirable property is to(More)
AIM The high level of comorbidity of coronary heart disease (CHD) and depressive disorders and general aspects of their pathogenesis is an actual problem of modern research. Authors studied the content of cholesterol, platelet serotonin, platelet aggregation, activity of pro-inflammatory markers in CHD patients with comorbid depressive disorders. MATERIAL(More)
We present a review of existing models for evaluating treatment-resistant depression (TRD). Their main advantages and drawbacks are identified, and the potential for using them in clinical practice is assessed. A new spectral model of TRD is presented, which considers the clinical spectrum of types (variants) of TRD; this model requires further development.
We present a review of the literature on clinical presentations, diagnosis, treatment and prevention of neuroendocrine dysfunctions (NED) in patients with mental disorders during psychopharmacological treatment. Prolactinemia syndrome, metabolic syndrome and dysthyreosis are considered. Risk factors for NED and practical recommendations on diagnostic and(More)